Increased oxidative activity in human blood neutrophils and monocytes after spinal cord injury

• Published in: Experimental neurology Vol. 215; no. 2; pp. 308 - 316
• Main Authors: Bao, Feng, Bailey, Christopher S., Gurr, Kevin R., Bailey, Stewart I., Rosas-Arellano, M. Patricia, Dekaban, Gregory A., Weaver, Lynne C.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.02.2009; Elsevier
• Subjects: Adult; Aged, 80 and over; Analysis of Variance; Biological and medical sciences; Cyclooxygenase 2 - metabolism; Female; Fluoresceins; Humans; Inflammation; Injuries of the nervous system and the skull. Diseases due to physical agents; Lipid Peroxidation - physiology; Macrophage; Male; Medical sciences; Middle Aged; Monocytes - metabolism; Neurology; Neutrophil; Neutrophils - metabolism; NF-kappa B - metabolism; Nitric Oxide Synthase Type II - metabolism; Oxidative damage; Oxidative enzyme; Peroxidase; Reactive Oxygen Species - blood; Rhodamines; Spinal Cord Injuries - blood; Trauma; Traumas. Diseases due to physical agents; Young Adult; NADPH; DHR123; Oxidative enzyme; COX-2; fMLP; gp91 phox; Oxidative damage; DCF; R123; CNS; TBARS; Inflammation; MDA; MPO; Trauma; DCFH-DA; TBA; RCF; ANOVA; KPBS; SCI; iNOS; Neutrophil; Macrophage; Human; Nervous system diseases; Monocyte; Enzyme; Spinal cord trauma; Central nervous system disease; Spinal cord disease

Traumatic injury can cause a systemic inflammatory response, increasing oxidative activity of circulating leukocytes and potentially exacerbating the original injury, as well as causing damage to initially unaffected organs. Although the importance of intraspinal inflammation after human spinal cord...