Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging

• Published in: Nature neuroscience Vol. 25; no. 6; pp. 818 - 831
• Main Authors: Wang, Chaoyue, Martins-Bach, Aurea B, Alfaro-Almagro, Fidel, Douaud, Gwenaëlle, Klein, Johannes C, Llera, Alberto, Fiscone, Cristiana, Bowtell, Richard, Elliott, Lloyd T, Smith, Stephen M, Tendler, Benjamin C, Miller, Karla L
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.06.2022; Nature Publishing Group US
• Subjects: Biobanks; Biological Specimen Banks; Brain; Brain - diagnostic imaging; Brain - pathology; Brain mapping; Brain Mapping - methods; Calcification; Calcification (ectopic); Calcium (extracellular); Epidemiology; Extracellular matrix; Genetic diversity; Genetic variance; Genomes; Imaging techniques; Iron; Iron - analysis; Magnetic permeability; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic susceptibility; Mapping; Markers; Medical imaging; Myelin; Nervous system; Neuroimaging; Phenotype; Phenotypes; Prospective Studies; Resource; Statistical analysis; Susceptibility; Therapeutic applications; United Kingdom; United Kingdom; United Kingdom > UK

A key aim in epidemiological neuroscience is identification of markers to assess brain health and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an emerging magnetic resonance imaging technique that measures tissue magnetic susceptibility and has been shown to detect...