Increased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia
Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ systems (proteinuria, thrombocytopenia, renal insufficiency, liver involvement, cerebral symptoms or pulmonary edema). Preeclampsia is known to b...
Saved in:
Published in | Scientific reports Vol. 9; no. 1; p. 1550 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
07.02.2019
Nature Publishing Group UK |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ systems (proteinuria, thrombocytopenia, renal insufficiency, liver involvement, cerebral symptoms or pulmonary edema). Preeclampsia is known to be associated with significant dyslipidemia, but the cause or mechanism of this metabolic aberration is not clear. Quantitative analysis of cholesterol precursors and metabolites can reveal metabolic signatures of cholesterol, and provide insight into cholesterol biosynthetic and degradation pathways. We undertook this study to compare the metabolic signatures of cholesterol in serum and amniotic fluid collected from women who delivered in the late preterm period. Matching serum and amniotic fluid samples were collected from women who delivered in the late preterm period (34-0/7-36-6/7 weeks), had undergone amniocentesis within 3 days of delivery, had no evidence of rupture of membranes or intra-amniotic infection/inflammation, and who had not received antenatal corticosteroid prior to amniocentesis. Patients were classified into 3 groups according to the etiology of their preterm birth: Group 1, preeclampsia; Group 2, spontaneous preterm labor; Group 3, other maternal medical indications for iatrogenic preterm birth. Quantitative metabolite profiling of cholesterols was performed using gas chromatography-mass spectrometry. A total of 39 women were included in the analysis (n = 14 in Group 1, n = 16 in Group 2, n = 9 in Group 3). In maternal blood, patients in Group 1 had significantly higher ratios of cholesterol/desmosterol and cholesterol/7-dehydrocholesterol (which represent 24- and 7-reductase enzyme activity, respectively) than those in Group 3 (p < 0.05 for each), which suggests increased cholesterol biosynthesis. In contrast, patients in Group 1 had significantly decreased ratios of individual cholesterol esters/cholesterol and total cholesterol esters/cholesterol than those in Groups 3 (p < 0.01 for each), suggesting increased reverse cholesterol transport. No differences in cholesterol ratios were found in amniotic fluid among the 3 groups. In conclusion, the metabolic signatures of cholesterol suggest increased cholesterol biosynthesis and accumulation in the maternal blood (but not amniotic fluid) of women with preeclampsia. |
---|---|
AbstractList | Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ systems (proteinuria, thrombocytopenia, renal insufficiency, liver involvement, cerebral symptoms or pulmonary edema). Preeclampsia is known to be associated with significant dyslipidemia, but the cause or mechanism of this metabolic aberration is not clear. Quantitative analysis of cholesterol precursors and metabolites can reveal metabolic signatures of cholesterol, and provide insight into cholesterol biosynthetic and degradation pathways. We undertook this study to compare the metabolic signatures of cholesterol in serum and amniotic fluid collected from women who delivered in the late preterm period. Matching serum and amniotic fluid samples were collected from women who delivered in the late preterm period (34-0/7–36-6/7 weeks), had undergone amniocentesis within 3 days of delivery, had no evidence of rupture of membranes or intra-amniotic infection/inflammation, and who had not received antenatal corticosteroid prior to amniocentesis. Patients were classified into 3 groups according to the etiology of their preterm birth: Group 1, preeclampsia; Group 2, spontaneous preterm labor; Group 3, other maternal medical indications for iatrogenic preterm birth. Quantitative metabolite profiling of cholesterols was performed using gas chromatography-mass spectrometry. A total of 39 women were included in the analysis (n = 14 in Group 1, n = 16 in Group 2, n = 9 in Group 3). In maternal blood, patients in Group 1 had significantly higher ratios of cholesterol/desmosterol and cholesterol/7-dehydrocholesterol (which represent 24- and 7-reductase enzyme activity, respectively) than those in Group 3 (p < 0.05 for each), which suggests increased cholesterol biosynthesis. In contrast, patients in Group 1 had significantly decreased ratios of individual cholesterol esters/cholesterol and total cholesterol esters/cholesterol than those in Groups 3 (p < 0.01 for each), suggesting increased reverse cholesterol transport. No differences in cholesterol ratios were found in amniotic fluid among the 3 groups. In conclusion, the metabolic signatures of cholesterol suggest increased cholesterol biosynthesis and accumulation in the maternal blood (but not amniotic fluid) of women with preeclampsia. Abstract Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ systems (proteinuria, thrombocytopenia, renal insufficiency, liver involvement, cerebral symptoms or pulmonary edema). Preeclampsia is known to be associated with significant dyslipidemia, but the cause or mechanism of this metabolic aberration is not clear. Quantitative analysis of cholesterol precursors and metabolites can reveal metabolic signatures of cholesterol, and provide insight into cholesterol biosynthetic and degradation pathways. We undertook this study to compare the metabolic signatures of cholesterol in serum and amniotic fluid collected from women who delivered in the late preterm period. Matching serum and amniotic fluid samples were collected from women who delivered in the late preterm period (34-0/7–36-6/7 weeks), had undergone amniocentesis within 3 days of delivery, had no evidence of rupture of membranes or intra-amniotic infection/inflammation, and who had not received antenatal corticosteroid prior to amniocentesis. Patients were classified into 3 groups according to the etiology of their preterm birth: Group 1, preeclampsia; Group 2, spontaneous preterm labor; Group 3, other maternal medical indications for iatrogenic preterm birth. Quantitative metabolite profiling of cholesterols was performed using gas chromatography-mass spectrometry. A total of 39 women were included in the analysis (n = 14 in Group 1, n = 16 in Group 2, n = 9 in Group 3). In maternal blood, patients in Group 1 had significantly higher ratios of cholesterol/desmosterol and cholesterol/7-dehydrocholesterol (which represent 24- and 7-reductase enzyme activity, respectively) than those in Group 3 (p < 0.05 for each), which suggests increased cholesterol biosynthesis. In contrast, patients in Group 1 had significantly decreased ratios of individual cholesterol esters/cholesterol and total cholesterol esters/cholesterol than those in Groups 3 (p < 0.01 for each), suggesting increased reverse cholesterol transport. No differences in cholesterol ratios were found in amniotic fluid among the 3 groups. In conclusion, the metabolic signatures of cholesterol suggest increased cholesterol biosynthesis and accumulation in the maternal blood (but not amniotic fluid) of women with preeclampsia. |
ArticleNumber | 1550 |
Author | Moon, Ju-Yeon Norwitz, Errol R Jun, Jong Kwan Park, Joong Shin Park, Chan-Wook Choi, Man Ho Kim, Sun Min Kim, Byoung Jae Lee, Seung Mi Lim, Byeong-Yun |
Author_xml | – sequence: 1 givenname: Seung Mi orcidid: 0000-0002-2543-0408 surname: Lee fullname: Lee, Seung Mi organization: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea – sequence: 2 givenname: Ju-Yeon surname: Moon fullname: Moon, Ju-Yeon organization: College of Pharmacy, The Catholic University of Korea, Gyeonggi-do, Korea – sequence: 3 givenname: Byeong-Yun surname: Lim fullname: Lim, Byeong-Yun organization: Molecular Recognition Research Center, Korea Institute of Science & Technology, Seoul, Korea – sequence: 4 givenname: Sun Min surname: Kim fullname: Kim, Sun Min organization: Department of Obstetrics & Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea – sequence: 5 givenname: Chan-Wook surname: Park fullname: Park, Chan-Wook organization: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea – sequence: 6 givenname: Byoung Jae surname: Kim fullname: Kim, Byoung Jae organization: Department of Obstetrics & Gynecology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea – sequence: 7 givenname: Jong Kwan surname: Jun fullname: Jun, Jong Kwan organization: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea – sequence: 8 givenname: Errol R surname: Norwitz fullname: Norwitz, Errol R organization: Department of Obstetrics & Gynecology, Tufts University School of Medicine, Boston, MA, USA – sequence: 9 givenname: Man Ho surname: Choi fullname: Choi, Man Ho email: mh_choi@kist.re.kr organization: Molecular Recognition Research Center, Korea Institute of Science & Technology, Seoul, Korea. mh_choi@kist.re.kr – sequence: 10 givenname: Joong Shin surname: Park fullname: Park, Joong Shin email: jsparkmd@snu.ac.kr organization: Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea. jsparkmd@snu.ac.kr |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30733456$$D View this record in MEDLINE/PubMed |
BookMark | eNpdkU9rHiEQh6UkNGmaL9BDEXrpoduq4-66l0IJ_RMI5JKeZVbdvgZXt7obyLevb940pPXiwDz-mPF5RY5iio6QN5x95AzUpyJ5O6iGcdVA37d9Ay_IqWCybQQIcfSsPiHnpdyyeloxSD68JCfAegDZdqckX0aTHRZn6ehTuY_rzhVfKEZL0Zht3gKuPkWaJmp2KbiyupwC9ZHOWMuIgS4By4wf6LitNKaV4hx9Wr2hU9i83aNLdo0zAeeleHxNjicMxZ0_3mfk57evNxc_mqvr75cXX64aI4GtDW8BO2mRWVsnHXFogVlhejVNHXSoJoVjazjAaJ1oBR8mJUEqhZPqAKCDM_L5kLts4-yscXHNGPSS_Yz5Xif0-t9O9Dv9K93pGt9LJmvA-8eAnH5vdXM9-2JcCBhd2ooWQgxsEJJBRd_9h96mbf85leJ917OhG1ilxIEyOZWS3fQ0DGd6b1UfrOpqVT9Y1fvot8_XeHry1yH8AYLHoMY |
CitedBy_id | crossref_primary_10_1055_s_0040_1714135 crossref_primary_10_3390_metabo12070590 crossref_primary_10_3390_ijms242216363 crossref_primary_10_3389_fmed_2021_688312 crossref_primary_10_1021_envhealth_3c00206 crossref_primary_10_2147_CLEP_S353019 crossref_primary_10_1097_HJH_0000000000002596 crossref_primary_10_1016_j_freeradbiomed_2019_05_026 crossref_primary_10_1038_s41598_020_72852_4 crossref_primary_10_3390_biomedicines11082328 crossref_primary_10_3390_ijms241411357 crossref_primary_10_1038_s41598_021_00270_1 crossref_primary_10_1016_j_redox_2022_102406 crossref_primary_10_1007_s11906_024_01299_z crossref_primary_10_3390_biom14060691 crossref_primary_10_3390_metabo14010054 crossref_primary_10_1016_j_jlr_2021_100118 crossref_primary_10_3389_fmolb_2023_1173030 crossref_primary_10_1080_01443615_2023_2259982 |
Cites_doi | 10.1016/S0140-6736(06)68397-9 10.1055/s-2007-1016250 10.1016/j.placenta.2011.03.012 10.1067/mob.2000.104207 10.1016/j.jsbmb.2015.02.012 10.1161/HYPERTENSIONAHA.115.05445 10.1515/jpm.2011.135 10.1194/jlr.D040790 10.1016/S0735-1097(00)00527-1 10.1067/mob.2001.117679 10.1093/aje/kwu145 10.1097/00001648-199605000-00016 10.1080/01443615.2017.1286463 10.1016/j.ajog.2011.07.017 10.1016/j.numecd.2011.04.010 10.1186/s12944-018-0698-4 10.1136/bmj.325.7356.157 10.1097/AOG.0b013e31829fc38c 10.1194/jlr.M071985 10.1016/B978-0-12-387042-1.00007-1 10.1016/j.ajog.2013.09.010 10.1007/s00404-013-2750-y 10.3109/10641955.2010.525277 10.1097/AOG.0b013e3181fdfb11 10.1016/j.jsbmb.2015.04.014 10.1186/s12884-016-0902-3 10.1080/09513590500097382 10.1194/jlr.M036699 10.1080/09513590400018108 10.1016/j.jsbmb.2015.09.024 10.1056/NEJMoa1409065 10.1159/000087205 |
ContentType | Journal Article |
Copyright | This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2019 |
Copyright_xml | – notice: This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2019 |
DBID | NPM AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PIMPY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM |
DOI | 10.1038/s41598-018-37757-3 |
DatabaseName | PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Science Database Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | PubMed CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | Publicly Available Content Database CrossRef PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2045-2322 |
EndPage | 1550 |
ExternalDocumentID | 10_1038_s41598_018_37757_3 30733456 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: ; |
GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ADBBV ADRAZ AENEX AFKRA AFPKN AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS EJD ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO NPM OK1 PIMPY PQQKQ PROAC PSQYO RIG RNT RNTTT RPM SNYQT UKHRP AAYXX CITATION 7XB 8FK K9. PQEST PQUKI PRINS Q9U 7X8 AFGXO 5PM |
ID | FETCH-LOGICAL-c430t-153a64da0dd456ba9530d2c78ff636a8f8ab5c133bde25219f843488af8633363 |
IEDL.DBID | RPM |
ISSN | 2045-2322 |
IngestDate | Tue Sep 17 21:08:58 EDT 2024 Fri Aug 16 09:46:34 EDT 2024 Fri Sep 13 07:18:48 EDT 2024 Fri Aug 23 01:04:17 EDT 2024 Sat Sep 28 08:36:21 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c430t-153a64da0dd456ba9530d2c78ff636a8f8ab5c133bde25219f843488af8633363 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0002-2543-0408 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367404/ |
PMID | 30733456 |
PQID | 2176709690 |
PQPubID | 2041939 |
PageCount | 1 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6367404 proquest_miscellaneous_2229092403 proquest_journals_2176709690 crossref_primary_10_1038_s41598_018_37757_3 pubmed_primary_30733456 |
PublicationCentury | 2000 |
PublicationDate | 2019-02-07 |
PublicationDateYYYYMMDD | 2019-02-07 |
PublicationDate_xml | – month: 02 year: 2019 text: 2019-02-07 day: 07 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: London |
PublicationTitle | Scientific reports |
PublicationTitleAlternate | Sci Rep |
PublicationYear | 2019 |
Publisher | Nature Publishing Group Nature Publishing Group UK |
Publisher_xml | – name: Nature Publishing Group – name: Nature Publishing Group UK |
References | U Iftikhar (37757_CR9) 2010; 60 S Sahu (37757_CR20) 2009; 53 B Lorentzen (37757_CR24) 1998; 16 N Sattar (37757_CR27) 2002; 325 DB Nelson (37757_CR6) 2014; 210 37757_CR1 RA Rajaratnam (37757_CR13) 2000; 35 HH Son (37757_CR19) 2014; 55 M Saucedo (37757_CR5) 2013; 122 KS Khan (37757_CR3) 2006; 367 CJ Berg (37757_CR4) 2010; 116 37757_CR34 A Ghio (37757_CR26) 2011; 55 Y Kocyigit (37757_CR8) 2004; 19 Publications Committee, S.f.M.-F.M. & Sibai, B.M (37757_CR32) 2011; 205 U Pecks (37757_CR33) 2012; 40 HD Mistry (37757_CR30) 2017; 58 F Parazzini (37757_CR25) 1996; 7 G Lupattelli (37757_CR14) 2011; 21 FC Brownfoot (37757_CR35) 2016; 16 JN Martin Jr. (37757_CR2) 2012; 31 C Contini (37757_CR31) 2018; 17 CN Spracklen (37757_CR10) 2014; 180 BH Yoon (37757_CR16) 2000; 182 HH Son (37757_CR12) 2015; 149 G Bayhan (37757_CR7) 2005; 21 S Kharb (37757_CR28) 2017; 37 HS Seo (37757_CR11) 2015; 153 MR Hentschke (37757_CR23) 2013; 54 H Uzun (37757_CR21) 2005; 60 JS Park (37757_CR17) 2001; 185 HH Son (37757_CR18) 2016; 155 SM Lee (37757_CR15) 2011; 32 A Rohatgi (37757_CR29) 2014; 371 T Emet (37757_CR22) 2013; 288 |
References_xml | – volume: 367 start-page: 1066 year: 2006 ident: 37757_CR3 publication-title: Lancet doi: 10.1016/S0140-6736(06)68397-9 contributor: fullname: KS Khan – volume: 16 start-page: 33 year: 1998 ident: 37757_CR24 publication-title: Semin Reprod Endocrinol doi: 10.1055/s-2007-1016250 contributor: fullname: B Lorentzen – volume: 32 start-page: 516 year: 2011 ident: 37757_CR15 publication-title: Placenta doi: 10.1016/j.placenta.2011.03.012 contributor: fullname: SM Lee – volume: 182 start-page: 675 year: 2000 ident: 37757_CR16 publication-title: Am J Obstet Gynecol doi: 10.1067/mob.2000.104207 contributor: fullname: BH Yoon – volume: 149 start-page: 138 year: 2015 ident: 37757_CR12 publication-title: J Steroid Biochem Mol Biol doi: 10.1016/j.jsbmb.2015.02.012 contributor: fullname: HH Son – ident: 37757_CR34 doi: 10.1161/HYPERTENSIONAHA.115.05445 – volume: 40 start-page: 287 year: 2012 ident: 37757_CR33 publication-title: J Perinat Med doi: 10.1515/jpm.2011.135 contributor: fullname: U Pecks – volume: 55 start-page: 155 year: 2014 ident: 37757_CR19 publication-title: J Lipid Res doi: 10.1194/jlr.D040790 contributor: fullname: HH Son – volume: 35 start-page: 1185 year: 2000 ident: 37757_CR13 publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(00)00527-1 contributor: fullname: RA Rajaratnam – volume: 185 start-page: 1156 year: 2001 ident: 37757_CR17 publication-title: Am J Obstet Gynecol doi: 10.1067/mob.2001.117679 contributor: fullname: JS Park – volume: 180 start-page: 346 year: 2014 ident: 37757_CR10 publication-title: Am J Epidemiol doi: 10.1093/aje/kwu145 contributor: fullname: CN Spracklen – volume: 53 start-page: 365 year: 2009 ident: 37757_CR20 publication-title: Indian J Physiol Pharmacol contributor: fullname: S Sahu – volume: 7 start-page: 306 year: 1996 ident: 37757_CR25 publication-title: Epidemiology doi: 10.1097/00001648-199605000-00016 contributor: fullname: F Parazzini – volume: 37 start-page: 610 year: 2017 ident: 37757_CR28 publication-title: J Obstet Gynaecol doi: 10.1080/01443615.2017.1286463 contributor: fullname: S Kharb – volume: 205 start-page: 191 year: 2011 ident: 37757_CR32 publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2011.07.017 contributor: fullname: Publications Committee, S.f.M.-F.M. & Sibai, B.M – volume: 21 start-page: 620 year: 2011 ident: 37757_CR14 publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2011.04.010 contributor: fullname: G Lupattelli – volume: 17 start-page: 49 year: 2018 ident: 37757_CR31 publication-title: Lipids Health Dis doi: 10.1186/s12944-018-0698-4 contributor: fullname: C Contini – volume: 325 start-page: 157 year: 2002 ident: 37757_CR27 publication-title: BMJ doi: 10.1136/bmj.325.7356.157 contributor: fullname: N Sattar – ident: 37757_CR1 – volume: 122 start-page: 752 year: 2013 ident: 37757_CR5 publication-title: Obstet Gynecol doi: 10.1097/AOG.0b013e31829fc38c contributor: fullname: M Saucedo – volume: 58 start-page: 1186 year: 2017 ident: 37757_CR30 publication-title: J Lipid Res doi: 10.1194/jlr.M071985 contributor: fullname: HD Mistry – volume: 55 start-page: 133 year: 2011 ident: 37757_CR26 publication-title: Adv Clin Chem doi: 10.1016/B978-0-12-387042-1.00007-1 contributor: fullname: A Ghio – volume: 210 start-page: 66 e1 year: 2014 ident: 37757_CR6 publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2013.09.010 contributor: fullname: DB Nelson – volume: 288 start-page: 49 year: 2013 ident: 37757_CR22 publication-title: Arch Gynecol Obstet doi: 10.1007/s00404-013-2750-y contributor: fullname: T Emet – volume: 31 start-page: 79 year: 2012 ident: 37757_CR2 publication-title: Hypertens Pregnancy doi: 10.3109/10641955.2010.525277 contributor: fullname: JN Martin Jr. – volume: 60 start-page: 432 year: 2010 ident: 37757_CR9 publication-title: J Pak Med Assoc contributor: fullname: U Iftikhar – volume: 116 start-page: 1302 year: 2010 ident: 37757_CR4 publication-title: Obstet Gynecol doi: 10.1097/AOG.0b013e3181fdfb11 contributor: fullname: CJ Berg – volume: 153 start-page: 72 year: 2015 ident: 37757_CR11 publication-title: J Steroid Biochem Mol Biol doi: 10.1016/j.jsbmb.2015.04.014 contributor: fullname: HS Seo – volume: 16 year: 2016 ident: 37757_CR35 publication-title: BMC Pregnancy Childbirth doi: 10.1186/s12884-016-0902-3 contributor: fullname: FC Brownfoot – volume: 21 start-page: 1 year: 2005 ident: 37757_CR7 publication-title: Gynecol Endocrinol doi: 10.1080/09513590500097382 contributor: fullname: G Bayhan – volume: 54 start-page: 2658 year: 2013 ident: 37757_CR23 publication-title: J Lipid Res doi: 10.1194/jlr.M036699 contributor: fullname: MR Hentschke – volume: 19 start-page: 267 year: 2004 ident: 37757_CR8 publication-title: Gynecol Endocrinol doi: 10.1080/09513590400018108 contributor: fullname: Y Kocyigit – volume: 155 start-page: 9 year: 2016 ident: 37757_CR18 publication-title: J Steroid Biochem Mol Biol doi: 10.1016/j.jsbmb.2015.09.024 contributor: fullname: HH Son – volume: 371 start-page: 2383 year: 2014 ident: 37757_CR29 publication-title: N Engl J Med doi: 10.1056/NEJMoa1409065 contributor: fullname: A Rohatgi – volume: 60 start-page: 195 year: 2005 ident: 37757_CR21 publication-title: Gynecol Obstet Invest doi: 10.1159/000087205 contributor: fullname: H Uzun |
SSID | ssj0000529419 |
Score | 2.4137168 |
Snippet | Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ... Abstract Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 1550 |
SubjectTerms | Amniocentesis Amniotic fluid Biosynthesis Birth Cholesterol Corticosteroids Dyslipidemia Edema Enzymatic activity Esters Etiology Gas chromatography Liver Mass spectroscopy Metabolism Metabolites Pre-eclampsia Preeclampsia Pregnancy complications Premature birth Proteinuria Reductase Renal insufficiency Thrombocytopenia |
SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEB7SlEIvJenTzQMVemvNei1Zj1MpJWEptKcG9mb0pIasvIntQ_59R7Z3222hZwlkazQznzQz3wC85yULlQ4y54WwOTOU5ioonzPhlXRFEahI1cjfvvPVDfu6rtZHsNrVwqS0yp1NHA21a216I18gdE5UY3iZW2iTXgFsv_i0vctT_6gUZ52baTyCx8sSYQWebLEW-9eWFM9iSzVXzRRULjr0XKm6bClRx0SFmnbomf6Bm39nTf7hhq5P4NmMH8nnSeCncOTjc3gydZR8eAH3qO8pzdw7Ypq2e4iI77qmIzo6oq0dNnO3LtIGkgzfyJPQ3pImEoSuIx802SKg3uiPxAw9iW1P9CY2LS5Hwu3QuDQ1pY54i2dp2zX6JdxcX_34ssrntgq5ZbToc7RxmjOnC-cQPRmtKlq40goZAqdcyyC1qSzeXY3zJXp3FSSjqOcoUU4p5fQVHMc2-jdAUPmVLNHcS10xa7jxiD-dCk7p0umSZ_Bht6X1dmLPqMeoN5X1JIAaBVCPAqhpBue7Xa9nTerq33LP4N1-GHUgBTZ09O2AcxJpvUrMghm8noS0Xy7ZMIr_mYE4EN9-QuLXPhyJzc-RZxt3Q7CCvf3_Z53BUwRRaszkFudw3N8P_gKBSm8uxzP4C-fG6g0 priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB7SlJZcQps-4jyKCrmlbh1LlqVDKKUkhEJ6ykJuRrIkatiVt2sbsv8-Iz-WpMmpZ8kIz_MbpPkG4ISnzGXKiZgneRkzTWksnbQxy60UJkkczUM38vVvfjVjv26z2y2Yxh2NAmyeLe3CPKnZav717u_6Ozr8-dAyLr41mIRCo9iZQHfJM3SaF_AyZZQFi78e4f7A9Z1KdibH3pnnP92B18HsKQsjrR-mqif4899nlA_y0uUb2B0BJfkxWMBb2LJ-D14NIybX72CFASC8O7eG6Kpu1h4BX1M1RHlDVFl2i3F8F6kdCcLoiRPqOak8QSzbE0STJSLshfpCdNcSX7dELXxV43HEzbvKhK3hLYkt0biWTaXew-zy4ubnVTzOWYhLRpM2xqCnODMqMQb_WiuZ0cSkZS6c45Qr4YTSWYnFrDY2xXQvnUDhCoEq5pRSTj_Atq-93QeC0UCKFOO_UBkrNdcWAamRzkiVGpXyCE4nkRbLgU6j6K_BqSgGXRSoi6LXRUEjOJqkXkyWUWANFTjnsKqP4PNmGZ0i3HQob-sO9wQWexmoBiP4OChpc9yk3QjyR-rbbAiE249XfPWnJ95GaeQsYQf__eUh7CDgkv2r7_wItttVZ48R1LT6U2-p92Ww9t4 priority: 102 providerName: Scholars Portal |
Title | Increased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia |
URI | https://www.ncbi.nlm.nih.gov/pubmed/30733456 https://www.proquest.com/docview/2176709690/abstract/ https://search.proquest.com/docview/2229092403 https://pubmed.ncbi.nlm.nih.gov/PMC6367404 |
Volume | 9 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZJSksupc_Ubbqo0FvrrGPJehzbkBAKG0JpYG9G1oMa1vIS24f8-45ke9m0t158kYxszYzmGzTzDUKfWU5doZxIWcZ1SitCUumkTSm3Upgsc4SHauTVDbu-oz_WxfoAFXMtTEza11V95jfNma9_x9zKbaOXc57Y8nZ1wQjjNKPLQ3TICdkL0UdC71zSczkVyGRELDtwUqGQ7FyAOfECjOoYPQu6TWjoW73vj_4BmX_nSu45n6sX6PmEGvG38eteogPrX6GnYx_Jh9foHqw8JJdbg6u67R48oLqu7rDyBiuth2bq0YVbh8NxF9kR2g2uPQbAGlmg8RZgdKO-4mrosW97rBpft7AcdpuhNmFqSBixGjRo29XqDbq7uvx1cZ1OzRRSTUnWp3CyKUaNyoyBv66ULEhmcs2Fc7CdSjihqkJDxFoZm4NPl05QAtYNcmSEEEbeoiPfevsOYTB5KXI45IUqqK5YZQF1GumMVLlROUvQl3lLy-3ImVHGu24iylEWJciijLIoSYJO510vJ_vpSgiUArEchO4J-rQbBs0P1xnK23aAOYGqXgY-wQSdjELaLTdLN0H8kfh2EwKr9uMRULbIrj0p1_v_fvMDOgZUJWNqNz9FR_39YD8CcumrBejrmi_Qk--XN7c_FzH-h-eKikXU4T-z2_ON |
link.rule.ids | 230,315,733,786,790,870,891,12083,21416,24346,27957,27958,31754,31755,33779,33780,43345,43840,53827,53829,74102,74659 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwEB3BVgguiG8CLRiJG0RNY8exT4hWrRZoVwi1Um-RHdsiUtdZmuTQf8848S4slTjbkhM_z8yzPX4D8J7nzBXKiZRnZZ0yTWkqnbQpK60UJsscLcNr5LMFn1-wr5fFZTxw62Ja5donjo7atHU4I99H6hykxnAz92n1Kw1Vo8LtaiyhcRd2GMWtygx2Do8X339sTlnCPRY7kPG1TEbFfocRK7wqOxBoW2WBFrYdkW7RzH-zJf8KPyeP4GHkjeTzBPRjuGP9E7g3VZK8eQrXaOchvdwaopu2u_HI67qmI8oboup6WMYqXaR1JDi8UR-hvSKNJ0hZRx1oskIivVQfiR564tueqKVvWhyOuKuhMaFrSBmxNa6hVdeoZ3Bxcnx-NE9jOYW0ZjTrU_RtijOjMmOQNWklC5qZvC6Fc5xyJZxQuqhxz6qNzTGqSycYRftGJDmllNPnMPOtty-BoNFLkaObF6pgtebaIu800hmpcqNynsCH9ZRWq0k1oxpvu6moJgAqBKAaAahoArvrWa-iBXXVH7wTeLdpxrUfLjSUt-2AfYJYvQyKggm8mEDaDBd8F8X_TKDcgm_TIehqb7f45ueor42zUbKMvfr_Z72F-_Pzs9Pq9Mvi22t4gERKjtnc5S7M-uvB7iFZ6fWbuCJ_A8WQ6qY |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagFYgL4tkGWjASN4g2jR0_TghKV-W1qhCVerMcP9RIXWdpkkP_PePEu7AgcbYlJ_7m8dkznkHoNSupr7QXOSu4yWlNSC69dDnlTgpbFJ7w-Br524KdntPPF9VFyn_qUlrl2iaOhtq2Jt6Rz4A6x1JjcJib-ZQWcfZx_m71M48dpGKkNbXTuI12OWUVSPjuh5PF2ffNjUuMadEjmV7OFETMOvBe8YXZkQA94xVo27Z3-ody_p05-Ycrmj9A9xOHxO8n0B-iWy48QnemrpI3j9E16HxMNXcW103b3QTgeF3TYR0s1sYMy9SxC7ceR-M31kpor3ATMNDXsSY0XgGpXuq3uB56HNoe62VoWlgO-6uhsXFqTB9xBuRp1TX6CTqfn_w4Ps1Ta4XcUFL0Odg5zajVhbXAoGotK1LY0nDhPSNMCy90XRk4v9bWleDhpReUgK4DqowQwshTtBPa4PYRBgMgRQkmX-iKmprVDjiold5KXVpdsgy9WW-pWk0VNNQY-SZCTQAoAECNACiSoYP1rqukTZ36jX2GXm2GQQ9icEMH1w4wJxaul7G6YIb2JpA2y0U7RuA_M8S34NtMiDW2t0dCcznW2obd4LSgz_7_WS_RXRBG9fXT4stzdA84lRwTu_kB2umvB3cIvKWvXySB_AWqPO7j |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Increased+biosynthesis+and+accumulation+of+cholesterol+in+maternal+plasma%2C+but+not+amniotic+fluid+in+pre-eclampsia&rft.jtitle=Scientific+reports&rft.au=Lee%2C+Seung+Mi&rft.au=Moon%2C+Ju-Yeon&rft.au=Lim%2C+Byeong-Yun&rft.au=Kim%2C+Sun+Min&rft.date=2019-02-07&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=9&rft_id=info:doi/10.1038%2Fs41598-018-37757-3&rft_id=info%3Apmid%2F30733456&rft.externalDBID=PMC6367404 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |