C-Peptide Induces Vascular Smooth Muscle Cell Proliferation: Involvement of Src-Kinase, Phosphatidylinositol 3-Kinase, and Extracellular Signal-Regulated Kinase 1/2 - Walcher, Daniel; Babiak, Christina; Poletek, Paulina; Rosenkranz, Stephan; Bach, Helga; Betz, Susanne; Durst, Renate; Grüb, Miriam; Hombach, Vinzenz; Strong, Jack; Marx, Nikolaus (Circulation research, 2006)
Keywords: Animals; Arteriosclerosis - metabolism; Arteriosclerosis - pathology; Biological and medical sciences; C-Peptide - pharmacology; Cell Proliferation - drug effects; Cells, Cultured; Cyclin D1 - metabolism; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - metabolism; Diabetic Angiopathies - pathology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzyme Activation - drug effects; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fundamental and applied biological sciences. Psychology; Humans; Intracellular Membranes - metabolism; Medical sciences; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Muscle, Smooth, Vascular - enzymology; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - enzymology; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation - drug effects; Phosphotransferases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Rats; Retinoblastoma Protein - metabolism; Signal Transduction; src-Family Kinases - metabolism; Vertebrates: cardiovascular system; Endocrinopathy; Cell proliferation; Extracellular signal-regulated protein kinase; proliferation; Enzyme; Transferases; Diabetes mellitus; Smooth muscle; C-Peptide; 1-Phosphatidylinositol 3-kinase; Restenosis; smooth muscle cells; Vertebrata; Mammalia; Kinase; Circulatory system