Phenotypic psychiatric characterization of children with Williams syndrome and response of those with ADHD to methylphenidate treatment

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 159B; no. 1; pp. 13 - 20
• Main Authors: Green, Tamar, Avda, Sarit, Dotan, Inbar, Zarchi, Omer, Basel-Vanagaite, Lina, Zalsman, Gil, Weizman, Abraham, Gothelf, Doron
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2012; Wiley-Liss; Wiley Subscription Services, Inc
• Subjects: ADHD; Adolescent; Adolescents; Adult and adolescent clinical studies; Anxiety; anxiety disorders; Anxiety disorders. Neuroses; Attention Deficit Disorder with Hyperactivity - complications; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention deficit hyperactivity disorder; Behavior disorders; Biological and medical sciences; Case-Control Studies; Central Nervous System Stimulants - pharmacology; Central Nervous System Stimulants - therapeutic use; Child; Children; Chromosome aberrations; Cognitive ability; Developmental disabilities; Developmental Disabilities - complications; Developmental Disabilities - psychology; Female; Genetics; Humans; Longitudinal Studies; Male; Medical genetics; Medical sciences; Mental disorders; Methylphenidate; Methylphenidate - pharmacology; Methylphenidate - therapeutic use; Obsessive-Compulsive Disorder - complications; Obsessive-compulsive disorders; obsessive-compulsive symptoms; Phenotype; Phenotypes; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Serotonin Uptake Inhibitors - pharmacology; Serotonin Uptake Inhibitors - therapeutic use; Stereotyped Behavior - drug effects; Williams syndrome; Williams Syndrome - complications; Williams Syndrome - drug therapy; Williams Syndrome - psychology; Chromosomal aberration; Human; obsessive-compulsive symptoms; Obsessive compulsive disorder; ADHD; CNS stimulant; Psychotropic; Anxiety disorder; anxiety disorders; Williams syndrome; Characterization; Response; Symptomatology; Phenotype; Treatment; Piperidine derivatives; Child; Methylphenidate

Williams syndrome (WS) is associated with cognitive deficits, special behavioral phenotype, and high rates of psychiatric disorders. The aims of the present study were: (1) To compare the rates of psychiatric disorders and repetitive behaviors in children with WS to children with idiopathic developm...