Experimental porcine nephropathy: changes of renal function and structure perorally induced by crystalline ochratoxin A

• Published in: Acta pathologica et microbiologica Scandinavica. Section A. Pathology Vol. 84; no. 5; pp. 429 - 434
• Main Authors: Krogh, P, Elling, F, Gyrd-Hansen, N, Hald, B, Larsen, A.E, Lillehoj, E.B, Madsen, A, Mortensen, H.P, Ravnskov, U
• Format: Journal Article
• Language: English
• Published: Denmark 01.07.1976
• Subjects: Adipose Tissue - metabolism; Animals; Creatinine - blood; crystalline ochratoxin A; Female; Glucose Tolerance Test; histopathology; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; kidney diseases; Kidney Diseases - chemically induced; Kidney Diseases - pathology; Kidney Function Tests; kidneys; Liver - metabolism; Muscles - metabolism; nephrotoxicity; ochratoxicosis; ochratoxin A; Ochratoxins - metabolism; oral administration; renal function; Swine

Nine pigs were fed crystalline ochratoxin A in amounts corresponding to a feed level of 1 mg per kg for 3 months. The only observable lesion developed was a kidney damage, identical to the naturally occurring porcine nephropathy. The changes of renal function was characterized by impairment of proxi...