Experimental porcine nephropathy: changes of renal function and structure perorally induced by crystalline ochratoxin A

Nine pigs were fed crystalline ochratoxin A in amounts corresponding to a feed level of 1 mg per kg for 3 months. The only observable lesion developed was a kidney damage, identical to the naturally occurring porcine nephropathy. The changes of renal function was characterized by impairment of proxi...

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Published inActa pathologica et microbiologica Scandinavica. Section A. Pathology Vol. 84; no. 5; pp. 429 - 434
Main Authors Krogh, P, Elling, F, Gyrd-Hansen, N, Hald, B, Larsen, A.E, Lillehoj, E.B, Madsen, A, Mortensen, H.P, Ravnskov, U
Format Journal Article
LanguageEnglish
Published Denmark 01.07.1976
Subjects
Adipose Tissue - metabolism
Animals
Creatinine - blood
crystalline ochratoxin A
Female
Glucose Tolerance Test
histopathology
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
kidney diseases
Kidney Diseases - chemically induced
Kidney Diseases - pathology
Kidney Function Tests
kidneys
Liver - metabolism
Muscles - metabolism
nephrotoxicity
ochratoxicosis
ochratoxin A
Ochratoxins - metabolism
oral administration
renal function
Swine
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Summary:Nine pigs were fed crystalline ochratoxin A in amounts corresponding to a feed level of 1 mg per kg for 3 months. The only observable lesion developed was a kidney damage, identical to the naturally occurring porcine nephropathy. The changes of renal function was characterized by impairment of proximal tubular function, indicated by a decrease of the ratio TmPAH/CIn, of the ability to concentrate urine, and by an increased urinary excretion of glucose. The decrease of the ratio TmPAH/CIn is correlated with time of exposure to ochratoxin A. The changes of renal structure were characterized by degeneration of the proximal tubules, leading to tubular atrophy accompanied by interstitial fibrosis. At the end of the experiment the kidney, liver, adipose and muscular tissue of the slaughtered pigs contained sizable amounts of ochratoxin A residues. As the pigs would have passed the meat inspection this represents a possible health problem. The changes observed in this study are identical to those observed by feeding to pigs grains naturally contaminated with ochratoxin A.
Bibliography:http://hdl.handle.net/10113/29569
ISSN:0365-4184
DOI:10.1111/j.1699-0463.1976.tb00137.x