Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans

• Published in: Pain (Amsterdam) Vol. 152; no. 6; pp. 1289 - 1297
• Main Authors: Lenz, Harald, Raeder, Johan, Draegni, Tomas, Heyerdahl, Fridtjof, Schmelz, Martin, Stubhaug, Audun
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier B.V 01.06.2011; Lippincott Williams & Wilkins, Inc; Elsevier
• Subjects: Adult; Analgesics, Opioid - adverse effects; Biological and medical sciences; Blood Pressure - drug effects; Cold-pressor test; Cross-Over Studies; Cyclooxygenase Inhibitors - therapeutic use; Double-Blind Method; Drug Interactions; Electrical pain model; Fundamental and applied biological sciences. Psychology; Humans; Hyperalgesia - chemically induced; Hyperalgesia - prevention & control; Isoxazoles - administration & dosage; Ketorolac; Ketorolac - administration & dosage; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Opioid-induced hyperalgesia; Pain - drug therapy; Pain - etiology; Pain Measurement; Pain Threshold - drug effects; Parecoxib; Physical Stimulation - adverse effects; Piperidines - adverse effects; Remifentanil; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Time Factors; Vertebrates: nervous system and sense organs; Young Adult; Opioid-induced hyperalgesia; Parecoxib; Ketorolac; Cold-pressor test; Remifentanil; Electrical pain model; Human; Pain sensitivity; Temperature; Cold; Electrical stimulus; Environmental factor; Electrical model; Transcutaneous stimulation; Hyperalgesia; Pain; Placebo
• ISSN: 0304-3959; 1872-6623; 1872-6623
• DOI: 10.1016/j.pain.2011.02.007

Opioids may enhance pain sensitivity resulting in opioid-induced hyperalgesia (OIH). Activation of spinal cyclooxygenase may play a role in the development of OIH. The aim of this study was to demonstrate remifentanil-induced postinfusion hyperalgesia in an electrical pain and a cold pain model, and...