The alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine activates the plasminogen activator inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases - Vidal, Berta; Parra, Maribel; Jardí, Mercè; Saito, Shin'ichi; Appella, Ettore; Muñoz-Cánoves, Pura (Thrombosis and haemostasis, 2005)
Keywords: 3T3 Cells; Alkylating Agents - pharmacology; Animals; Ataxia Telangiectasia Mutated Proteins; Caffeine - pharmacology; Carcinogens - pharmacology; Cell Cycle Proteins - metabolism; Cell Death; DNA-Activated Protein Kinase - deficiency; DNA-Activated Protein Kinase - metabolism; DNA-Binding Proteins - deficiency; DNA-Binding Proteins - metabolism; Humans; Methylnitronitrosoguanidine - pharmacology; Mice; Mice, Knockout; Nuclear Proteins - deficiency; Nuclear Proteins - metabolism; Phosphorylation; Plasminogen Activator Inhibitor 1 - genetics; Protein-Serine-Threonine Kinases - deficiency; Protein-Serine-Threonine Kinases - metabolism; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumor Suppressor Proteins - deficiency; Tumor Suppressor Proteins - metabolism