Effects of Bolus and Continuous Nasogastric Feeding on Gastric Emptying, Small Bowel Water Content, Superior Mesenteric Artery Blood Flow, and Plasma Hormone Concentrations in Healthy Adults: A Randomized Crossover Study
We aimed to demonstrate the effect of continuous or bolus nasogastric feeding on gastric emptying, small bowel water content, and splanchnic blood flow measured by magnetic resonance imaging (MRI) in the context of changes in plasma gastrointestinal hormone secretion. Nasogastric/nasoenteral tube fe...
Saved in:
Published in | Annals of surgery Vol. 263; no. 3; p. 450 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.03.2016
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | We aimed to demonstrate the effect of continuous or bolus nasogastric feeding on gastric emptying, small bowel water content, and splanchnic blood flow measured by magnetic resonance imaging (MRI) in the context of changes in plasma gastrointestinal hormone secretion.
Nasogastric/nasoenteral tube feeding is often complicated by diarrhea but the contribution of feeding strategy to the etiology is unclear.
Twelve healthy adult male participants who underwent nasogastric intubation before a baseline MRI scan, received 400 mL of Resource Energy (Nestle) as a bolus over 5 minutes or continuously over 4 hours via pump in this randomized crossover study. Changes in gastric volume, small bowel water content, and superior mesenteric artery blood flow and velocity were measured over 4 hours using MRI and blood glucose and plasma concentrations of insulin, peptide YY, and ghrelin were assayed every 30 minutes.
Bolus nasogastric feeding led to significant elevations in gastric volume (P < 0.0001), superior mesenteric artery blood flow (P < 0.0001), and velocity (P = 0.0011) compared with continuous feeding. Both types of feeding reduced small bowel water content, although there was an increase in small bowel water content with bolus feeding after 90 minutes (P < 0.0068). Similarly, both types of feeding led to a fall in plasma ghrelin concentration although this fall was greater with bolus feeding (P < 0.0001). Bolus feeding also led to an increase in concentrations of insulin (P = 0.0024) and peptide YY (P < 0.0001), not seen with continuous feeding.
Continuous nasogastric feeding does not increase small bowel water content, thus fluid flux within the small bowel is not a major contributor to the etiology of tube feeding-related diarrhea. |
---|---|
AbstractList | We aimed to demonstrate the effect of continuous or bolus nasogastric feeding on gastric emptying, small bowel water content, and splanchnic blood flow measured by magnetic resonance imaging (MRI) in the context of changes in plasma gastrointestinal hormone secretion.
Nasogastric/nasoenteral tube feeding is often complicated by diarrhea but the contribution of feeding strategy to the etiology is unclear.
Twelve healthy adult male participants who underwent nasogastric intubation before a baseline MRI scan, received 400 mL of Resource Energy (Nestle) as a bolus over 5 minutes or continuously over 4 hours via pump in this randomized crossover study. Changes in gastric volume, small bowel water content, and superior mesenteric artery blood flow and velocity were measured over 4 hours using MRI and blood glucose and plasma concentrations of insulin, peptide YY, and ghrelin were assayed every 30 minutes.
Bolus nasogastric feeding led to significant elevations in gastric volume (P < 0.0001), superior mesenteric artery blood flow (P < 0.0001), and velocity (P = 0.0011) compared with continuous feeding. Both types of feeding reduced small bowel water content, although there was an increase in small bowel water content with bolus feeding after 90 minutes (P < 0.0068). Similarly, both types of feeding led to a fall in plasma ghrelin concentration although this fall was greater with bolus feeding (P < 0.0001). Bolus feeding also led to an increase in concentrations of insulin (P = 0.0024) and peptide YY (P < 0.0001), not seen with continuous feeding.
Continuous nasogastric feeding does not increase small bowel water content, thus fluid flux within the small bowel is not a major contributor to the etiology of tube feeding-related diarrhea. |
Author | Marciani, Luca Lobo, Dileep N Costigan, Carolyn Macdonald, Ian A Chowdhury, Abeed H Murray, Kathryn Bowling, Timothy E Hoad, Caroline L |
Author_xml | – sequence: 1 givenname: Abeed H surname: Chowdhury fullname: Chowdhury, Abeed H organization: Nottingham Digestive Diseases Centre, National Institute for Health Research, Biomedical Research Unit, Nottingham University Hospitals, Queen's Medical Centre, Nottingham, UK †Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK ‡Metabolic Physiology Group, University of Nottingham, Nottingham, UK §Department of Gastroenterology, Nottingham University Hospitals NHS Trust, Nottingham, UK – sequence: 2 givenname: Kathryn surname: Murray fullname: Murray, Kathryn – sequence: 3 givenname: Caroline L surname: Hoad fullname: Hoad, Caroline L – sequence: 4 givenname: Carolyn surname: Costigan fullname: Costigan, Carolyn – sequence: 5 givenname: Luca surname: Marciani fullname: Marciani, Luca – sequence: 6 givenname: Ian A surname: Macdonald fullname: Macdonald, Ian A – sequence: 7 givenname: Timothy E surname: Bowling fullname: Bowling, Timothy E – sequence: 8 givenname: Dileep N surname: Lobo fullname: Lobo, Dileep N |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25549202$$D View this record in MEDLINE/PubMed |
BookMark | eNpNUNtO3DAQtaqismz7BxWaD2DBzmWT9C2s9lJpgarbqo9oEo8hlWOvbAcUvpWPqYFF6ryMzhmdM3PmhH001hBjXwU_F7wqLnbb-pz_V0II_oFNRJ6UMyEyfsxOvP8b-azkxSd2nOR5ViU8mbDnpVLUBg9WwaXVgwc0EhbWhM4MNsJr9PYOfXBdCysi2Zk7sAbWB2rZ78MYuTPY9ah19HgkDX8wkHt1IRPiaNiT66yDK_KRoBdh7WIf4VJbK2Gl7ePZ6-YfGn2PsLGujxFfLNqocBg6azx0BjaEOtyPUMtBB_8NavgZdbbvnije7az39iHu3oVBjp_ZkULt6cuhT9nv1fLXYjPb3qy_L-rtrM1SzmeUYlal1IisqFCm83leqCZvSmqFKhSWMbUqmpyElKQqPidMUUTUZoUSRYnJlJ2--e6Hpid5u3ddj268fX9z8g8cPIWX |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1097/SLA.0000000000001110 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
EISSN | 1528-1140 |
ExternalDocumentID | 25549202 |
Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | England |
GeographicLocations_xml | – name: England |
GroupedDBID | --- .-D .3C .55 .GJ .XZ .Z2 01R 0R~ 1J1 23M 2WC 354 3O- 40H 4Q1 4Q2 4Q3 53G 5GY 5VS 6J9 71W 77Y 7O~ AAAAV AAAXR AAEJM AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AAQKA AARTV AASCR AASOK AASXQ AAUEB AAXQO ABASU ABBUW ABDIG ABJNI ABOCM ABPMR ABPPZ ABVCZ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACLDA ACOAL ACRZS ACWDW ACWRI ACXJB ACXNZ ADBBV ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEBDS AEETU AENEX AFCHL AFDTB AFEXH AFSOK AFUWQ AGINI AHJKT AHOMT AHQNM AHRYX AHVBC AI. AIJEX AINUH AJIOK AJJEV AJNWD AJNYG AJZMW AKULP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW ASPBG AVWKF AWKKM AZFZN BAWUL BOYCO BQLVK BS7 BYPQX C45 CGR CS3 CUY CVF DIK DIWNM DUNZO E.X E3Z EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FEDTE FL- FW0 GNXGY GQDEL H0~ HLJTE HVGLF HZ~ IH2 IKREB IKYAY IN~ IPNFZ J5H JF7 JF9 JG8 JK3 JK8 K-A K-F K8S KD2 KMI L-C L7B M18 N4W N9A NPM N~7 N~B N~M O9- OAG OAH OBH OCB OCUKA ODA ODMTH OGEVE OHH OHYEH OJAPA OK1 OL1 OLB OLG OLH OLU OLV OLW OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OVOZU OWBYB OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P R58 RIG RLZ RPM RXW S4R S4S T8P TAF TEORI TR2 TSPGW UQX V2I VH1 VVN W3M WH7 WOQ WOW X3V X3W X7M XXN XYM YFH YOC ZFV ZGI ZXP ZY1 ZZMQN ~H1 |
ID | FETCH-LOGICAL-c4300-e3a493eb1479ad36657fb5b8ec1f7fa8eedf7b5e1ddef906ea3a1e1dc47f178a2 |
IngestDate | Tue Oct 15 23:50:43 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c4300-e3a493eb1479ad36657fb5b8ec1f7fa8eedf7b5e1ddef906ea3a1e1dc47f178a2 |
OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC4741393 |
PMID | 25549202 |
ParticipantIDs | pubmed_primary_25549202 |
PublicationCentury | 2000 |
PublicationDate | 2016-March |
PublicationDateYYYYMMDD | 2016-03-01 |
PublicationDate_xml | – month: 03 year: 2016 text: 2016-March |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Annals of surgery |
PublicationTitleAlternate | Ann Surg |
PublicationYear | 2016 |
References | 18513835 - Clin Nutr. 2008 Aug;27(4):608-13 20670666 - Appetite. 2010 Dec;55(3):407-12 18175750 - Am J Clin Nutr. 2008 Jan;87(1):156-61 19779010 - Am J Physiol Gastrointest Liver Physiol. 2009 Nov;297(5):G894-901 3557189 - Gut. 1987 Feb;28(2):166-70 1903408 - J Clin Gastroenterol. 1991 Apr;13(2):167-72 2454876 - Gut. 1988 Jun;29(6):762-8 6852464 - Gastroenterology. 1983 Jul;85(1):76-82 1875801 - Med Sci Sports Exerc. 1991 Mar;23(3):307-13 14612488 - Gut. 2003 Dec;52 Suppl 7:vii1-vii12 6996495 - Am J Physiol. 1980 Aug;239(2):G71-6 8524904 - Proc Nutr Soc. 1995 Jul;54(2):579-90 9712593 - BMJ. 1998 Aug 22;317(7157):495-501 20626735 - Aliment Pharmacol Ther. 2010 Sep;32(5):655-63 19759401 - Physiol Meas. 2009 Oct;30(10):1117-36 9107630 - Med Sci Sports Exerc. 1997 Apr;29(4):482-8 19909743 - Gastroenterology. 2010 Feb;138(2):469-77, 477.e1 23594839 - Eur J Clin Nutr. 2013 Jul;67(7):754-8 7829011 - Gut. 1994 Dec;35(12):1734-41 3410330 - Gut. 1988 Aug;29(8):1042-51 2105646 - Am J Med. 1990 Feb;88(2):91-3 727254 - Am J Physiol. 1978 Nov;235(5):E552-5 20554933 - Am J Physiol Regul Integr Comp Physiol. 2010 Sep;299(3):R960-7 23113932 - Neurogastroenterol Motil. 2013 Jan;25(1):e11-6 6706215 - Gut. 1984 Apr;25(4):365-74 3124596 - Am J Clin Nutr. 1988 Feb;47(2 Suppl):352-6 18029983 - Phys Med Biol. 2007 Dec 7;52(23):6909-22 19321590 - J Nutr. 2009 May;139(5):890-7 6785478 - JPEN J Parenter Enteral Nutr. 1981 Jan-Feb;5(1):73-5 8541703 - Nutrition. 1995 May-Jun;11(3):304-7 2919683 - Am J Physiol. 1989 Feb;256(2 Pt 1):G404-11 9700754 - Peptides. 1998;19(6):1049-53 3840109 - Gastroenterology. 1985 Nov;89(5):1070-7 9536931 - Gut. 1998 Feb;42(2):147-51 3114056 - Gut. 1987 Jun;28(6):681-7 8550855 - J Clin Invest. 1996 Jan 1;97(1):92-103 19553500 - Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R716-22 22649258 - J Nutr. 2012 Jul;142(7):1253-8 1997128 - Br J Nutr. 1991 Jan;65(1):15-9 6421429 - Br Med J (Clin Res Ed). 1984 Mar 3;288(6418):678-80 22129616 - Am J Physiol Regul Integr Comp Physiol. 2012 Feb 15;302(4):R391-9 |
References_xml | |
SSID | ssj0014807 |
Score | 2.4791667 |
Snippet | We aimed to demonstrate the effect of continuous or bolus nasogastric feeding on gastric emptying, small bowel water content, and splanchnic blood flow... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 450 |
SubjectTerms | Blood Flow Velocity - physiology Body Water - metabolism Cross-Over Studies Diarrhea - etiology England Enteral Nutrition - methods Gastric Emptying - physiology Gastrointestinal Hormones - blood Healthy Volunteers Humans Intestine, Small - physiology Intubation, Gastrointestinal Magnetic Resonance Imaging Male Mesenteric Artery, Superior - physiology Young Adult |
Title | Effects of Bolus and Continuous Nasogastric Feeding on Gastric Emptying, Small Bowel Water Content, Superior Mesenteric Artery Blood Flow, and Plasma Hormone Concentrations in Healthy Adults: A Randomized Crossover Study |
URI | https://www.ncbi.nlm.nih.gov/pubmed/25549202 |
Volume | 263 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1bb9owFMetsr3sZeq0-03nYW9pOhKbhOwtIBiaNh5Gq_WtshNnRSoJKqCKftZ9mJ1jOwl0nXZBKIKY3Di_OMf2OX8z9k5mPORFzn1seilf5ApvqZhHvo7CQmsuVCQpUfjLNJqcik9nvbODzuFO1NJmrY6zmzvzSv7HqrgO7UpZsv9g2WanuAI_o31xiRbG5V_ZeNQGYwzwQFZumfSm5uWGQlunclV9lzQzR-aN7WOKBgc-ulWjxXK9dXOazBY0Rj2orvWl902ScqLRrbKqBLMN6SFXpPhDuUom-j6lWNCtN6DAd298aYeITOoB-uOU34TOcFXSpHilDQBtgtZt5tPWS0n6Y2VT47_iltVifkP9zfTcpsBSE-O4N-rcqj2vdrK5TXBCdZ1fuJCAVOGltkkXiNKV3NaRI1fb5m6YVBbvoZ25SHtNP_iwMtIjZVPqNnK9I0HUhocda1ejh9hMDqwmVF3lh65Sne92CZgKXFgZ3F8eLFawePY5tYKX7oUPir2f41-2XBjYsKUmktAkk_-h9Jbcd13UYZ24T1X2lLqf3LAY5f_X-Z9J_P6u0yF1a7eLWy0l4zGdHLKHrqkDqeX2ETvQ5WP2wzELVQGGWUDLQ8ss7DALjlmoSnDMQs3sERhiwRALhlhwxGKR4xVaXsHyCoZXIF6PzJEtreBohX1aYV6CoxUsrR8ghZZVaFgFw-oTdjoenQwnvpthxM8E73Z9zaVIOLorIk5kzmkUslA91ddZUMSF7ONVFrHq6QCdgCLpRlpyGeC3TMRFEPdl-JTdK_HsnjPoCa5j0c3RvQvRKdcywbeKg1DlYV-J4AV7Zo1xvrQyMue1mV7-tuQVe9Ay_ZrdL_Ae02_QCV6rtwaMn8ZhuOQ |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+Bolus+and+Continuous+Nasogastric+Feeding+on+Gastric+Emptying%2C+Small+Bowel+Water+Content%2C+Superior+Mesenteric+Artery+Blood+Flow%2C+and+Plasma+Hormone+Concentrations+in+Healthy+Adults%3A+A+Randomized+Crossover+Study&rft.jtitle=Annals+of+surgery&rft.au=Chowdhury%2C+Abeed+H&rft.au=Murray%2C+Kathryn&rft.au=Hoad%2C+Caroline+L&rft.au=Costigan%2C+Carolyn&rft.date=2016-03-01&rft.eissn=1528-1140&rft.volume=263&rft.issue=3&rft.spage=450&rft_id=info:doi/10.1097%2FSLA.0000000000001110&rft_id=info%3Apmid%2F25549202&rft_id=info%3Apmid%2F25549202&rft.externalDocID=25549202 |