Ether lipids, sphingolipids and toxic 1‐deoxyceramides as hallmarks for lean and obese type 2 diabetic patients

• Published in: Acta Physiologica Vol. 232; no. 1; pp. e13610 - n/a
• Main Authors: Hannich, J. Thomas, Loizides‐Mangold, Ursula, Sinturel, Flore, Harayama, Takeshi, Vandereycken, Bart, Saini, Camille, Gosselin, Pauline, Brulhart‐Meynet, Marie‐Claude, Robert, Maud, Chanon, Stephanie, Durand, Christine, Paz Montoya, Jonathan, David, Fabrice P. A., Guessous, Idris, Pataky, Zoltan, Golay, Alain, Jornayvaz, François R., Philippe, Jacques, Dermitzakis, Emmanouil T., Brown, Steven A., Lefai, Etienne, Riezman, Howard, Dibner, Charna
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2021; Wiley
• Subjects: 1‐deoxyceramide; Adipocytes; Adipose tissue; Cell culture; Cell differentiation; Cytotoxicity; Diabetes; Diabetes mellitus (non-insulin dependent); Homeostasis; Life Sciences; lipid metabolism; lipidomics; Lipids; Mass spectroscopy; Obesity; Phenotypes; Phospholipids; Precision medicine; serum; Skeletal muscle; Sphingolipids; Type 2 diabetes in lean and obese subjects; visceral adipose tissue; 1-deoxyceramide; serum; lipidomics; lipid metabolism; Type 2 diabetes in lean and obese subjects; visceral adipose tissue

Aim The worldwide increase in obesity and type 2 diabetes (T2D) represents a major health challenge. Chronically altered lipids induced by obesity further promote the development of T2D, and the accumulation of toxic lipid metabolites in serum and peripheral organs may contribute to the diabetic phe...