Immune Response to Yersinia Outer Proteins and Other Yersinia pestis Antigens after Experimental Plague Infection in Mice

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Published inInfection and Immunity Vol. 67; no. 4; pp. 1922 - 1928
Main Authors BENNER, G. E, ANDREWS, G. P, BYRNE, W. R, STRACHAN, S. D, SAMPLE, A. K, HEATH, D. G, FRIEDLANDER, A. M
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.1999
Subjects
Animals
Anti-Infective Agents - therapeutic use
Antibodies, Bacterial - immunology
Antigens, Bacterial - immunology
Bacterial diseases
Bacterial Outer Membrane Proteins - immunology
Biological and medical sciences
Disease Models, Animal
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Experimental bacterial diseases and models
Female
Immunoblotting
Immunoglobulin G - immunology
Infectious diseases
Medical sciences
Mice
Microbial Immunity and Vaccines
Ofloxacin - therapeutic use
Plague - drug therapy
Plague - immunology
Sodium Dodecyl Sulfate
Time Factors
Yersinia pestis
Yersinia pestis - immunology
Membrane protein
Immune response
Antibody
Rodentia
External membrane
Yersinia pestis
Infection
Plague
Vertebrata
Antibiotic
Chemotherapy
Experimental disease
Mammalia
Treatment
Mouse
Bacteriosis
Bacteria
Antibacterial agent
Yersiniosis
Humoral immunity
Enterobacteriaceae
Online AccessGet full text

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Abstract Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
AbstractList ABSTRACT There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Such a model may replicate the clinical situation in humans and indicate which virulence determinants are expressed in vivo. Immunoglobulin G enzyme-linked immunosorbent assay and immunoblotting were performed by using purified, recombinant antigens including F1, V antigen, YpkA, YopH, YopM, YopB, YopD, YopN, YopE, YopK, plasminogen activator protease (Pla), and pH 6 antigen as well as purified lipopolysaccharide. The major antigens recognized by murine convalescent sera were F1, V antigen, YopH, YopM, YopD, and Pla. Early treatment with antibiotics tended to reduce the immune response and differences between antibiotic treatment regimens were noted. These results may indicate that only some virulence factors are expressed and/or immunogenic during infection. This information may prove useful for selecting potential vaccine candidates and for developing improved serologic diagnostic assays.
There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Such a model may replicate the clinical situation in humans and indicate which virulence determinants are expressed in vivo. Immunoglobulin G enzyme-linked immunosorbent assay and immunoblotting were performed by using purified, recombinant antigens including F1, V antigen, YpkA, YopH, YopM, YopB, YopD, YopN, YopE, YopK, plasminogen activator protease (Pla), and pH 6 antigen as well as purified lipopolysaccharide. The major antigens recognized by murine convalescent sera were F1, V antigen, YopH, YopM, YopD, and Pla. Early treatment with antibiotics tended to reduce the immune response and differences between antibiotic treatment regimens were noted. These results may indicate that only some virulence factors are expressed and/or immunogenic during infection. This information may prove useful for selecting potential vaccine candidates and for developing improved serologic diagnostic assays.
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Such a model may replicate the clinical situation in humans and indicate which virulence determinants are expressed in vivo. Immunoglobulin G enzyme-linked immunosorbent assay and immunoblotting were performed by using purified, recombinant antigens including F1, V antigen, YpkA, YopH, YopM, YopB, YopD, YopN, YopE, YopK, plasminogen activator protease (Pla), and pH 6 antigen as well as purified lipopolysaccharide. The major antigens recognized by murine convalescent sera were F1, V antigen, YopH, YopM, YopD, and Pla. Early treatment with antibiotics tended to reduce the immune response and differences between antibiotic treatment regimens were noted. These results may indicate that only some virulence factors are expressed and/or immunogenic during infection. This information may prove useful for selecting potential vaccine candidates and for developing improved serologic diagnostic assays.
There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Such a model may replicate the clinical situation in humans and indicate which virulence determinants are expressed in vivo. Immunoglobulin G enzyme-linked immunosorbent assay and immunoblotting were performed by using purified, recombinant antigens including F1, V antigen, YpkA, YopH, YopM, YopB, YopD, YopN, YopE, YopK, plasminogen activator protease (Pla), and pH 6 antigen as well as purified lipopolysaccharide. The major antigens recognized by murine convalescent sera were Fl, V antigen, YopH, YopM, YopD, and Pla. Early treatment with antibiotics tended to reduce the immune response and differences between antibiotic treatment regimens were noted. These results may indicate that only some virulence factors are expressed and/or immunogenic during infection. This information may prove useful for selecting potential vaccine candidates and for developing improved serologic diagnostic assays.
Author Gretchen E. Benner
David G. Heath
Gerard P. Andrews
Arthur M. Friedlander
W. Russell Byrne
Susan D. Strachan
Allen K. Sample
AuthorAffiliation Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702-5011
AuthorAffiliation_xml – name: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702-5011
Author_xml – sequence: 1
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  surname: BENNER
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  organization: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702-5011, United States
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  surname: ANDREWS
  fullname: ANDREWS, G. P
  organization: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702-5011, United States
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  givenname: W. R
  surname: BYRNE
  fullname: BYRNE, W. R
  organization: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702-5011, United States
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  givenname: S. D
  surname: STRACHAN
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  surname: SAMPLE
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Issue 4
Keywords Membrane protein
Immune response
Antibody
Rodentia
External membrane
Yersinia pestis
Infection
Plague
Vertebrata
Antibiotic
Chemotherapy
Experimental disease
Mammalia
Treatment
Mouse
Bacteriosis
Bacteria
Antibacterial agent
Yersiniosis
Humoral immunity
Enterobacteriaceae
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Present address: Department of Pathology & Area Lab Services, Landstuhl Regional Medical Center, Landstuhl, Germany.
Present address: IDEXX Laboratories, Inc., Westbrook, ME 04092.
Corresponding author. Mailing address: Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Frederick, MD 21702-5011. Phone: (301) 619-7341. Fax: (301) 619-2152. E-mail: friedlan@ncifcrf.gov.
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SSID ssj0014448
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There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of...
ABSTRACT There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the...
There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of...
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SourceType Open Access Repository
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StartPage 1922
SubjectTerms Animals
Anti-Infective Agents - therapeutic use
Antibodies, Bacterial - immunology
Antigens, Bacterial - immunology
Bacterial diseases
Bacterial Outer Membrane Proteins - immunology
Biological and medical sciences
Disease Models, Animal
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Experimental bacterial diseases and models
Female
Immunoblotting
Immunoglobulin G - immunology
Infectious diseases
Medical sciences
Mice
Microbial Immunity and Vaccines
Ofloxacin - therapeutic use
Plague - drug therapy
Plague - immunology
Sodium Dodecyl Sulfate
Time Factors
Yersinia pestis
Yersinia pestis - immunology
Title Immune Response to Yersinia Outer Proteins and Other Yersinia pestis Antigens after Experimental Plague Infection in Mice
URI http://iai.asm.org/content/67/4/1922.abstract
https://www.ncbi.nlm.nih.gov/pubmed/10085037
https://search.proquest.com/docview/17224364
https://search.proquest.com/docview/69634644
https://pubmed.ncbi.nlm.nih.gov/PMC96547
Volume 67
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