Comparative retrospective analysis of locoregional recurrence in unselected breast cancer patients treated with conventional versus hypofractionated radiotherapy at a tertiary cancer center?
Background: Role of hypofractionated radiotherapy (HFRT) in early breast cancer is established; comparatively, there are limited data for HFRT in locally advanced breast cancer (LABC). We report the impact of HFRT in unselected breast cancer patients in comparison with historically treated patients...
Saved in:
Published in | Journal of cancer research and therapeutics Vol. 16; no. 6; pp. 1314 - 1322 |
---|---|
Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
India
Wolters Kluwer India Pvt. Ltd
01.10.2020
Medknow Publications & Media Pvt. Ltd |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background: Role of hypofractionated radiotherapy (HFRT) in early breast cancer is established; comparatively, there are limited data for HFRT in locally advanced breast cancer (LABC). We report the impact of HFRT in unselected breast cancer patients in comparison with historically treated patients with conventional fractionated radiotherapy (CFRT).
Patients and Methods: Records of 463 breast cancer patients treated between January 09 and July 13 with CFRT (50 Gy/25 fr) or HFRT (42.4 Gy in 16 fractions or 40 Gy in 15 fractions) in two sequential periods were retrospectively reviewed. The analysis was done in August 2018. The primary endpoint was to compare the differences in locoregional recurrence rate.
Results: Of the 463 patients, 209 received CFRT and 254 received HFRT. The median age was 48 years (interquartile range: 40-56), premenopausal (CFRT: 23% vs. HFRT 39%, P = 0.005). The most common pathology was infiltrating ductal carcinoma (81%) with Grade III tumors (45%), estrogen receptor (+) was seen in 44%, triple-negative breast cancer in 34%, and Her2Neu (3+) were seen in 27%. Two hundred and fifty-four patients (54.5%) had undergone breast-conserving surgery (BCS) and 209 patients (45%) modified radical mastectomy (MRM). Nodal radiotherapy was delivered in 76% versus 64% in patients receiving CFRT versus HFRT, respectively (P = 0.005). With a median follow-up of 46 months in CFRT and 57 months in HFRT, 9/209 (4.3%) patients in CFRT and 7/254 (2.7%) in HFRT had locoregional relapse (LRR). The 4 years#39; actuarial local recurrence-free survival (LRFS) in CFRT versus HFRT was 95% versus 97% (P = 0.37). The mean estimated LRFS (local relapse-free survival) for CFRT is 113.4 months and for HFRT 94.2 months (P = 0.3).
Conclusions: The risk of local recurrence among patients of breast cancer treated with HFRT after BCS or MRM was not worse when compared to CFRT. |
---|---|
AbstractList | Role of hypofractionated radiotherapy (HFRT) in early breast cancer is established; comparatively, there are limited data for HFRT in locally advanced breast cancer (LABC). We report the impact of HFRT in unselected breast cancer patients in comparison with historically treated patients with conventional fractionated radiotherapy (CFRT).
Records of 463 breast cancer patients treated between January 09 and July 13 with CFRT (50 Gy/25 fr) or HFRT (42.4 Gy in 16 fractions or 40 Gy in 15 fractions) in two sequential periods were retrospectively reviewed. The analysis was done in August 2018. The primary endpoint was to compare the differences in locoregional recurrence rate.
Of the 463 patients, 209 received CFRT and 254 received HFRT. The median age was 48 years (interquartile range: 40-56), premenopausal (CFRT: 23% vs. HFRT 39%, P = 0.005). The most common pathology was infiltrating ductal carcinoma (81%) with Grade III tumors (45%), estrogen receptor (+) was seen in 44%, triple-negative breast cancer in 34%, and Her2Neu (3+) were seen in 27%. Two hundred and fifty-four patients (54.5%) had undergone breast-conserving surgery (BCS) and 209 patients (45%) modified radical mastectomy (MRM). Nodal radiotherapy was delivered in 76% versus 64% in patients receiving CFRT versus HFRT, respectively (P = 0.005). With a median follow-up of 46 months in CFRT and 57 months in HFRT, 9/209 (4.3%) patients in CFRT and 7/254 (2.7%) in HFRT had locoregional relapse (LRR). The 4 years#39; actuarial local recurrence-free survival (LRFS) in CFRT versus HFRT was 95% versus 97% (P = 0.37). The mean estimated LRFS (local relapse-free survival) for CFRT is 113.4 months and for HFRT 94.2 months (P = 0.3).
The risk of local recurrence among patients of breast cancer treated with HFRT after BCS or MRM was not worse when compared to CFRT. Background: Role of hypofractionated radiotherapy (HFRT) in early breast cancer is established; comparatively, there are limited data for HFRT in locally advanced breast cancer (LABC). We report the impact of HFRT in unselected breast cancer patients in comparison with historically treated patients with conventional fractionated radiotherapy (CFRT). Patients and Methods: Records of 463 breast cancer patients treated between January 09 and July 13 with CFRT (50 Gy/25 fr) or HFRT (42.4 Gy in 16 fractions or 40 Gy in 15 fractions) in two sequential periods were retrospectively reviewed. The analysis was done in August 2018. The primary endpoint was to compare the differences in locoregional recurrence rate. Results: Of the 463 patients, 209 received CFRT and 254 received HFRT. The median age was 48 years (interquartile range: 40-56), premenopausal (CFRT: 23% vs. HFRT 39%, P = 0.005). The most common pathology was infiltrating ductal carcinoma (81%) with Grade III tumors (45%), estrogen receptor (+) was seen in 44%, triple-negative breast cancer in 34%, and Her2Neu (3+) were seen in 27%. Two hundred and fifty-four patients (54.5%) had undergone breast-conserving surgery (BCS) and 209 patients (45%) modified radical mastectomy (MRM). Nodal radiotherapy was delivered in 76% versus 64% in patients receiving CFRT versus HFRT, respectively (P = 0.005). With a median follow-up of 46 months in CFRT and 57 months in HFRT, 9/209 (4.3%) patients in CFRT and 7/254 (2.7%) in HFRT had locoregional relapse (LRR). The 4 years#39; actuarial local recurrence-free survival (LRFS) in CFRT versus HFRT was 95% versus 97% (P = 0.37). The mean estimated LRFS (local relapse-free survival) for CFRT is 113.4 months and for HFRT 94.2 months (P = 0.3). Conclusions: The risk of local recurrence among patients of breast cancer treated with HFRT after BCS or MRM was not worse when compared to CFRT. Background: Role of hypofractionated radiotherapy (HFRT) in early breast cancer is established; comparatively, there are limited data for HFRT in locally advanced breast cancer (LABC). We report the impact of HFRT in unselected breast cancer patients in comparison with historically treated patients with conventional fractionated radiotherapy (CFRT). Patients and Methods: Records of 463 breast cancer patients treated between January 09 and July 13 with CFRT (50 Gy/25 fr) or HFRT (42.4 Gy in 16 fractions or 40 Gy in 15 fractions) in two sequential periods were retrospectively reviewed. The analysis was done in August 2018. The primary endpoint was to compare the differences in locoregional recurrence rate. Results: Of the 463 patients, 209 received CFRT and 254 received HFRT. The median age was 48 years (interquartile range: 40–56), premenopausal (CFRT: 23% vs. HFRT 39%, P = 0.005). The most common pathology was infiltrating ductal carcinoma (81%) with Grade III tumors (45%), estrogen receptor (+) was seen in 44%, triple-negative breast cancer in 34%, and Her2Neu (3+) were seen in 27%. Two hundred and fifty-four patients (54.5%) had undergone breast-conserving surgery (BCS) and 209 patients (45%) modified radical mastectomy (MRM). Nodal radiotherapy was delivered in 76% versus 64% in patients receiving CFRT versus HFRT, respectively (P = 0.005). With a median follow-up of 46 months in CFRT and 57 months in HFRT, 9/209 (4.3%) patients in CFRT and 7/254 (2.7%) in HFRT had locoregional relapse (LRR). The 4 years#39; actuarial local recurrence-free survival (LRFS) in CFRT versus HFRT was 95% versus 97% (P = 0.37). The mean estimated LRFS (local relapse-free survival) for CFRT is 113.4 months and for HFRT 94.2 months (P = 0.3). Conclusions: The risk of local recurrence among patients of breast cancer treated with HFRT after BCS or MRM was not worse when compared to CFRT. |
Author | Lal, Punita Agarwal, Amit Mishra, Anjali Misra, Shagun Chand, Gyan Kumar, Shaleen Agarwal, Gaurav Yadav, Rajan Agarwal, Sushma Das, K Kumar, Anup Mishra, S Verma, A Verma, Mranalini Senthil Kumar, S |
Author_xml | – sequence: 1 givenname: Rajan surname: Yadav fullname: Yadav, Rajan organization: Department of Radiotherapy, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 2 givenname: Punita surname: Lal fullname: Lal, Punita organization: Department of Radiotherapy, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 3 givenname: Sushma surname: Agarwal fullname: Agarwal, Sushma organization: Department of Radiotherapy, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 4 givenname: Shagun surname: Misra fullname: Misra, Shagun organization: Department of Radiotherapy, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 5 givenname: Mranalini surname: Verma fullname: Verma, Mranalini organization: Department of Radiotherapy, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 6 givenname: K surname: Das fullname: Das, K organization: Department of Radiotherapy, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 7 givenname: S surname: Senthil Kumar fullname: Senthil Kumar, S organization: Department of Radiotherapy, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 8 givenname: Anup surname: Kumar fullname: Kumar, Anup organization: Department of Biostatistics, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 9 givenname: S surname: Mishra fullname: Mishra, S organization: Department of Endosurgery, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 10 givenname: Amit surname: Agarwal fullname: Agarwal, Amit organization: Department of Endosurgery, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 11 givenname: Gaurav surname: Agarwal fullname: Agarwal, Gaurav organization: Department of Endosurgery, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 12 givenname: Anjali surname: Mishra fullname: Mishra, Anjali organization: Department of Endosurgery, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 13 givenname: Gyan surname: Chand fullname: Chand, Gyan organization: Department of Endosurgery, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 14 givenname: A surname: Verma fullname: Verma, A organization: Department of Endosurgery, SGPGIMS, Lucknow, Uttar Pradesh – sequence: 15 givenname: Shaleen surname: Kumar fullname: Kumar, Shaleen organization: Department of Radiotherapy, SGPGIMS, Lucknow, Uttar Pradesh |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33342790$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kUtv1DAUhS1URKeFPStkiXWKX5nYK4Si8lIlJFTWluPcMJlm4nDtzGj-HL8Np9NBbFhZPvc7R74-V-RiDCMQ8pqzG8WZfLf1mG6-1t_vrdTGcv2MrLgxulBc6guyYqaSBVdaXJKrGLeMlZUQ-gW5lFIqURm2Ir_rsJscutTvgSIkDHEC_3hzoxuOsY80dHQIPiD87EPWMuZnRBg90H6k8xhhyBZoaYPgYqLe5RHSKYfCmCJNWV7Ghz5tqA_jPqunpD1gnCPdHKfQofOP6kKia_uQNoBuOlKXqKMJMPUOj-dwnzMA378kzzs3RHj1dF6THx9v7-vPxd23T1_qD3eFV8KkoluDA-GYq4TrTAvGlQDVWspOVMqpijNeca1K7SvRNguhhaigEaU2a8kaeU3ennInDL9miMluw4x5hWhFKcXaiJKpTLET5fM3RoTOTtjv8qstZ3YpzC6F2X8Ky5Y3T8Fzs4P2r-HcUAbqE3AIQ944PgzzAdBm9mEMh_8GWy65sudy5R8sC7Mh |
CitedBy_id | crossref_primary_10_3389_fonc_2022_811794 crossref_primary_10_1016_j_jmir_2020_12_004 |
ContentType | Journal Article |
Copyright | 2020. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: 2020. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PIMPY PQEST PQQKQ PQUKI PRINS Q9U |
DOI | 10.4103/jcrt.JCRT_389_18 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database Research Library Research Library (Corporate) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) |
DatabaseTitleList | MEDLINE Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1998-4138 |
EndPage | 1322 |
ExternalDocumentID | 10_4103_jcrt_JCRT_389_18 33342790 10.4103/jcrt.JCRT_389_18_1314_Comparat |
Genre | Journal Article Comparative Study |
GroupedDBID | - 29K 2WC 3V. 53G 5GY 5VS 7X7 8FI 8G5 AAWTL ABDBF ABPTK ABUWG ACGFS ADACO ADBBV AENEX AFKRA AHMBA ALMA_UNASSIGNED_HOLDINGS AZQEC BAWUL BBAFP BCNDV BENPR BPHCQ BVXVI D-I DIK DU5 DWQXO E3Z EBD EBS EJD ESX F5P FYUFA GROUPED_DOAJ GUQSH GX1 IAO IEA IHR INH INR IOF IPO ITC KQ8 LI0 M1P M2O MBDVC M~E OBODZ OK1 P2P PIMPY PQEST PQQKQ PQUKI PRINS PROAC PSQYO RBI RIG RMW RNS SV3 TUS --- 88E 8FJ ABJNI ABXLX ALIPV CCPQU CGR CUY CVF ECM EIF EMOBN EOJEC GNUQQ H13 HMCUK IHE IL9 IPNFZ NPM OVD P6G TEORI TR2 UKHRP W3E XSB ~8M AAYXX CITATION 7XB 8FK K9. Q9U |
ID | FETCH-LOGICAL-c429t-f6eae2a0a72af9de9a5ee7633f274a47101718458c72dbf9de8227eb2589630b3 |
IEDL.DBID | BENPR |
ISSN | 0973-1482 |
IngestDate | Thu Oct 10 20:52:35 EDT 2024 Fri Aug 23 03:47:52 EDT 2024 Sat Sep 28 08:19:39 EDT 2024 Wed Dec 23 03:11:40 EST 2020 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 |
Keywords | Hypofractionated radiotherapy local relapse-free survival locally advanced breast cancer |
Language | English |
License | http://creativecommons.org/licenses/by-nc-sa/4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c429t-f6eae2a0a72af9de9a5ee7633f274a47101718458c72dbf9de8227eb2589630b3 |
OpenAccessLink | https://www.proquest.com/docview/2532692504?pq-origsite=%requestingapplication% |
PMID | 33342790 |
PQID | 2532692504 |
PQPubID | 226490 |
PageCount | 9 |
ParticipantIDs | proquest_journals_2532692504 crossref_primary_10_4103_jcrt_JCRT_389_18 pubmed_primary_33342790 wolterskluwer_medknow_10_4103_jcrt_JCRT_389_18_1314_Comparat |
ProviderPackageCode | RMW |
PublicationCentury | 2000 |
PublicationDate | 20201001 |
PublicationDateYYYYMMDD | 2020-10-01 |
PublicationDate_xml | – month: 10 year: 2020 text: 20201001 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | India |
PublicationPlace_xml | – name: India – name: Mumbai |
PublicationTitle | Journal of cancer research and therapeutics |
PublicationTitleAlternate | J Cancer Res Ther |
PublicationYear | 2020 |
Publisher | Wolters Kluwer India Pvt. Ltd Medknow Publications & Media Pvt. Ltd |
Publisher_xml | – name: Wolters Kluwer India Pvt. Ltd – name: Medknow Publications & Media Pvt. Ltd |
References | Whelan (key-10.4103/0973-1482.277814-3) 2002 Smith (key-10.4103/0973-1482.277814-7) 2011 key-10.4103/0973-1482.277814-5 Darby (key-10.4103/0973-1482.277814-10) 2003 Nandi (key-10.4103/0973-1482.277814-16) 2014 key-10.4103/0973-1482.277814-4 Chatterjee (key-10.4103/0973-1482.277814-15) 2016 Sarin (key-10.4103/0973-1482.277814-13) 1993 Hopwood (key-10.4103/0973-1482.277814-8) 2010 Thomas (key-10.4103/0973-1482.277814-18) 2006 Whelan (key-10.4103/0973-1482.277814-11) 2010 Yadav (key-10.4103/0973-1482.277814-17) 2007 START (key-10.4103/0973-1482.277814-2) 2008 McBain (key-10.4103/0973-1482.277814-6) 2003 START (key-10.4103/0973-1482.277814-1) 2008 Abhilash (key-10.4103/0973-1482.277814-14) 2016 Kouloulias (key-10.4103/0973-1482.277814-12) 2014 Haviland (key-10.4103/0973-1482.277814-9) 2013 |
References_xml | – start-page: 331 volume-title: The UK standardisation of breast radiotherapy (START) trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial year: 2008 ident: key-10.4103/0973-1482.277814-1 publication-title: Lancet Oncol contributor: fullname: START – start-page: 2505 volume-title: Hypofractionated radiotherapy for breast cancers – Preliminary results from a tertiary care center in Eastern India year: 2014 ident: key-10.4103/0973-1482.277814-16 publication-title: Asian Pac J Cancer Prev contributor: fullname: Nandi – start-page: 513 volume-title: Long-term results of hypofractionated radiation therapy for breast cancer year: 2010 ident: key-10.4103/0973-1482.277814-11 publication-title: N Engl J Med contributor: fullname: Whelan – start-page: 231 volume-title: Comparison of patient-reported breast, arm, and shoulder symptoms and body image after radiotherapy for early breast cancer: 5-year follow-up in the randomised standardisation of breast radiotherapy (START) trials year: 2010 ident: key-10.4103/0973-1482.277814-8 publication-title: Lancet Oncol contributor: fullname: Hopwood – start-page: 25 volume-title: Local recurrence of breast cancer following surgery and radiotherapy: Incidence and outcome year: 2003 ident: key-10.4103/0973-1482.277814-6 publication-title: Clin Oncol (R Coll Radiol) contributor: fullname: McBain – start-page: 705 volume-title: Adjuvant chemotherapy and acute toxicity in hypofractionated radiotherapy for early breast cancer year: 2014 ident: key-10.4103/0973-1482.277814-12 publication-title: World J Clin Cases contributor: fullname: Kouloulias – ident: key-10.4103/0973-1482.277814-5 – ident: key-10.4103/0973-1482.277814-4 – start-page: 139 volume-title: Cervical cancer: Treatment challenges in the developing world year: 2006 ident: key-10.4103/0973-1482.277814-18 publication-title: Radiother Oncol contributor: fullname: Thomas – start-page: 256 volume-title: Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: Nationwide cohort study of 90 000 Swedish women year: 2003 ident: key-10.4103/0973-1482.277814-10 publication-title: BMJ contributor: fullname: Darby – start-page: 285 volume-title: Therapeutic factors influencing the cosmetic outcome and late complications in the conservative management of early breast cancer year: 1993 ident: key-10.4103/0973-1482.277814-13 publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Sarin – start-page: e165 volume-title: Outcomes following a moderately hypofractionated adjuvant radiation (START B type) schedule for breast cancer in an unscreened non-caucasian population year: 2016 ident: key-10.4103/0973-1482.277814-15 publication-title: Clin Oncol (R Coll Radiol) contributor: fullname: Chatterjee – start-page: 75 volume-title: Patterns of relapse in locally advanced breast cancer treated with neoadjuvant chemotherapy followed by surgery and radiotherapy year: 2007 ident: key-10.4103/0973-1482.277814-17 publication-title: J Cancer Res Ther contributor: fullname: Yadav – start-page: 1086 volume-title: The UK standardisation of breast radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials year: 2013 ident: key-10.4103/0973-1482.277814-9 publication-title: Lancet Oncol contributor: fullname: Haviland – start-page: 1098 volume-title: The UK standardisation of breast radiotherapy (START) trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial year: 2008 ident: key-10.4103/0973-1482.277814-2 publication-title: Lancet contributor: fullname: START – start-page: 1143 volume-title: Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer year: 2002 ident: key-10.4103/0973-1482.277814-3 publication-title: J Natl Cancer Inst contributor: fullname: Whelan – start-page: 1177 volume-title: Comparison of hypofractionated radiation therapy versus conventional radiation therapy in post mastectomy breast cancer year: 2016 ident: key-10.4103/0973-1482.277814-14 publication-title: J Evid Based Med Healthc contributor: fullname: Abhilash – start-page: 59 volume-title: Fractionation for whole breast irradiation: An American Society for Radiation Oncology (ASTRO) evidence-based guideline year: 2011 ident: key-10.4103/0973-1482.277814-7 publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Smith |
SSID | ssj0057228 |
Score | 2.2783864 |
Snippet | Background: Role of hypofractionated radiotherapy (HFRT) in early breast cancer is established; comparatively, there are limited data for HFRT in locally... Role of hypofractionated radiotherapy (HFRT) in early breast cancer is established; comparatively, there are limited data for HFRT in locally advanced breast... |
SourceID | proquest crossref pubmed wolterskluwer |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1314 |
SubjectTerms | Adult Aged Aged, 80 and over Breast cancer Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Disease-Free Survival Female Humans Mastectomy Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - radiotherapy Radiation Dose Hypofractionation Radiation therapy Retrospective Studies Survival Rate Tertiary Care Centers Young Adult |
SummonAdditionalLinks | – databaseName: Medknow Open Access Journals dbid: W3E link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ti9QwEA7HCaKI6Pm2esp8kAPhqm3S9IUqIssdx8HJIXtwfgpJm-Iqbo-2q_TP-ducadLbFfGT3wpNX59JZiZ55gljL7nUNTdVFUgrUkxQrA4MT0wgcmNCE5eYOdPUwNnH5OQiPr2UlztsYi0Rq7Kkz239rxwTdP8Tx9IuP3mVioAULIsB7QHTYh4WU29OCvfGSeG6ZCSiuLD-kPNCrzEs7d991pX-UYzKRJjx3-CkwkIFKeJoGshlysetWa8f5lY54ygUb76Wbf_6dP5podDhK9oxZNur_RWq3mZ3fja0-t19G8nvWy7s-B6762NP-OC-8z7bsas9dvPMr67vsYNzp2M9HMJiU5bVHcIBnG8UrocH7Nd8oxkOre3bZirYBO1FTqCpAf1kQxs_ULCPzcpRCqq0sFzBWAiPl9gKDNHie3B4gNd57WBkwONpmiiGbW48EJFk3cGX4aqpW1eXMbZsdbX09WQD6B40EN9hqdthujkxUW37_iG7OD5azE8CvxFEUKK77IM6sdpyHeqU6zqvbK6ltTgwihph0-heSfQni2VWprwy1ALDntQaLjMcX0IjHrHdVbOyTxjIuCIJ_VxbG8Upr_NURomOTZJkuTRhNmOvJiDVldP7UJgnEeiKQFdboM_Y_oS08ubaKS4xIM5JGG7GHjv0r28khIh5mocz9vYPc1DfXenjP5-kyIjVhO3T_7v8GbtFHcYxEvfZbt-u7XOMrHrzYrT_3897KoU priority: 102 providerName: Wolters Kluwer Health |
Title | Comparative retrospective analysis of locoregional recurrence in unselected breast cancer patients treated with conventional versus hypofractionated radiotherapy at a tertiary cancer center? |
URI | http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=6;spage=1314;epage=1322;aulast=Yadav;type=0 https://www.ncbi.nlm.nih.gov/pubmed/33342790 https://www.proquest.com/docview/2532692504 |
Volume | 16 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ta9RAEF5sC6JI0fp2Wst8kILQ2GRfsgkIRY8rpdBylCvet2U32eApXs4kpeTP9be5k2x6J6IfQza7H2YyLzvPPEPIeyp0QU2eB8Iy6RIUqwNDYxOw1JjQ8Mxlzng1cHEZn13z87mY-wu32sMqB5vYGeq8zPCO_JgKF2ikSLh1svoV4NQorK76ERpbZIdGHMu0O18ml9OrwRYLSbvpqshJEyDjZV-o5FHIjr9nVfPxfHw1U85nKxz6semY_oo2H5MntyUWsOsfHX59wwudPiW7PnyEz728n5EHdrlHHl74AvkeOZz2VNTtEczWnVX1ERzCdE1S3T4nd-M17TdUtqnKoecStOcpgbIA5-pKnN2A8bpblnVsTpmFxRK6Xnb3ic3BILK9gQw1qAJP1VpDB2J3r_GuFzbh7YBYkJsavrWrsqj61opuZaXzhW8Ja0E3oAEhCwtdtcPmCCa11ckLcn06mY3PAj_LIcicx2uCIrbaUh1qSXWR5jbVwlpn21jh0mLtPCTy9iRcJJmkucEVLnKRLu0XiTMRoWEvyfayXNrXBATPkQU_1dZGXNIilSKKNTdxnKTChMmIfBgEqVY9ZYdyqQ4KXaHQ1YbQR2R_kLTyP2-t1qo2Iq966d9vxBjjVKbhiHz6Qx3Uz7578Z8nqYhFXA2yffP_c9-SRxTz-g40uE-2m-rGvnPBT2MOyJacywOv5-7pK5v8BpV2DZM |
link.rule.ids | 315,786,790,12083,21416,27489,27955,27956,31752,33777,43343,43838 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ta9RAEB60gi-IaLX1tOp8kILQ2GSzmxcQihyWs_ZKkSvct2U32dBTvFyTFMmf87e5k2x6J6Kfs9l8mMm8PvMMwFsmVMF0nnvChLFNUIzyNIu0F6Za-5pnNnOm0sD0LJpc8JO5mLuCW-1glYNN7Ax1XmZUIz9kwgYaKRFuHa2uPNoaRd1Vt0LjNtzhYchJz-P5TcIlYtbtViVGGo_4Lvs2JQ_88PBbVjXvT8ZfZ9J6bEkrPzbd0l-x5gN4-LOk9nX9vUOvb_ig48fwyAWP-LGX9hO4ZZbbcHfq2uPbsH_eE1G3Bzhbz1XVB7iP52uK6vYp_BqvSb-xMk1VDhOXqBxLCZYFWkdX0uYGitbtsazjcsoMLpbYTbLbV0yOmnDtDWakPxU6otYaOwi7fUyVXtwEtyMhQa5rvGxXZVH1gxXdyUrlCzcQ1qJqUCEBFhaqaofLCUpqqqNncHH8aTaeeG6Tg5dZf9d4RWSUYcpXMVNFmptUCWOsZQsLmxQr6x-JtSfhIslilms6YeOW2Cb9IrEGwtfhDmwty6V5Dih4Thz4qTIm4DEr0lgEkeI6ipJUaD8ZwbtBkHLVE3ZIm-iQ0CUJXW4IfQR7g6Sl-3VruVa0Eez20r-5KLRKxuLUH8GHP9RB_uhnF__5JRmEAZeDbF_8_7tv4N5kNj2Vp5_PvryE-4wy_A4-uAdbTXVtXtkwqNGvO13_DULqDUM |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparative+retrospective+analysis+of+locoregional+recurrence+in+unselected+breast+cancer+patients+treated+with+conventional+versus+hypofractionated+radiotherapy+at+a+tertiary+cancer+center%3F&rft.jtitle=Journal+of+cancer+research+and+therapeutics&rft.au=Yadav%2C+Rajan&rft.au=Lal%2C+Punita&rft.au=Agarwal%2C+Sushma&rft.au=Misra%2C+Shagun&rft.date=2020-10-01&rft.pub=Medknow+Publications+%26+Media+Pvt.+Ltd&rft.issn=0973-1482&rft.eissn=1998-4138&rft.volume=16&rft.issue=5&rft.spage=1314&rft.epage=1322&rft_id=info:doi/10.4103%2Fjcrt.JCRT_389_18 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0973-1482&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0973-1482&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0973-1482&client=summon |