Association Between Serum Selenium Levels with Rheumatoid Arthritis

• Published in: Biological trace element research Vol. 172; no. 1; pp. 46 - 52
• Main Authors: Yu, Na, Fang Han, Xiaojun Lin, Chun Tang, Jinghua Ye, Xiaoyan Cai
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2016; Springer Nature B.V
• Subjects: absorption; Arthritis, Rheumatoid - blood; Asia; atomic absorption spectrometry; Atomic absorption spectrophotometry; Biochemistry; Biomedical and Life Sciences; Biotechnology; blood serum; Case-Control Studies; confidence interval; Correlation analysis; Europe; Humans; Life Sciences; Meta-analysis; naphthaleneacetic acid; neutron activation analysis; Nutrition; Oncology; races; Rheumatoid arthritis; Selenium; Selenium - blood; Spectral analysis; Spectrometry; spectrophotometers; Spectrophotometry; Asia; United States; Europe; Rheumatoid arthritis; Selenium; Meta-analysis
• ISSN: 0163-4984; 1559-0720; 1559-0720
• DOI: 10.1007/s12011-015-0558-2

There are conflicting reports on the correlation between serum selenium (Se) levels with rheumatoid arthritis (RA). Through a meta-analysis approach, the aim of the present study is to clarify the relationship between serum Se levels with RA. We searched literatures that met our predefined criteria in PubMed, ScienceDirect, and OVID published as of September 2015. Ten eligible articles with 14 case–control studies involving 716 subjects were identified. Overall, pooled analysis indicated that subjects with RA had lower serum levels of Se than the healthy controls (standardized mean difference (SMD) = −1.347, 95 % confidence interval (CI) = [−1.872, −0.823], p