Release of ibuprofen from PEG-PLLA electrospun fibers containing poly(ethylene glycol)-b-poly(α-hydroxy octanoic acid) as an additive

• Published in: Chinese journal of polymer science Vol. 28; no. 3; pp. 417 - 425
• Main Authors: Wang, Hao, Song, Hong-rui, Chen, Xue-si, Deng, Ying-jie
• Format: Journal Article
• Language: English
• Published: Heidelberg Chinese Chemical Society and Institute of Chemistry, CAS 01.05.2010; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chinese Academy of Sciences, Changchun 130022, China%School of Pharmaceutical Engineering, Pharmaceutical University, Shenyang 110016, China%State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chinese Academy of Sciences, Changchun 130022, China%School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
• Subjects: Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Condensed Matter Physics; Industrial Chemistry/Chemical Engineering; Polymer Sciences; Drug release; Poly(lactic acid); Fiber; Ibuprofen; Proteinase K; Electrospinning; Poly; hydroxy octanoic acid; Poly(α-hydroxy octanoic acid)
• ISSN: 0256-7679; 1439-6203
• DOI: 10.1007/s10118-010-9041-x

Poly( α -hydroxy octanoic acid) was first used as an additive for the preparation of electrospun ultra-fine fibers of poly(ethylene glycol)- b -poly(L-lactide) (PEG-PLLA). Ibuprofen was loaded in the electrospun ultra-fine fibers. The results from environmental scanning electron microscopy (ESEM), wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC) demonstrated that ibuprofen could be perfectly entrapped in the fibers electrospun from PEG-PLLA using α -hydroxy octanoic acid or PEG- b -poly( α -hydroxy octanoic acid) (PEG-PHOA) as additives. Compared with electrospun PEG-PLLA fibers which entrapped 20 wt% ibuprofen, the PEG-PLLA electrospun fibers containing PEG-PHOA exhibited integral and robust after 1 week incubated in 37°C, pH 7.4 phosphate buffer solution with 10 μg/mL proteinase K. Compared with electrospun fibers without PEG-PHOA, the concentration of proteinase K in release media had less effect on the release rate of ibuprofen. An unique release profile was found from PEG-PLLA fiber after the incorporation of PEG-PHOA. Enzyme degradation experiments demonstrated that PEG-PHOA but not α -hydroxy octanoic acid monomer was the crucial factor for integrity maintenance of the electrospun fibers, which may be due to the enzyme degradation tolerance property of the PEG-PHOA polymer additive.