NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization

• Published in: Frontiers in immunology Vol. 6; p. 495
• Main Authors: Hadad, Uzi, Thauland, Timothy J, Martinez, Olivia M, Butte, Manish J, Porgador, Angel, Krams, Sheri M
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.09.2015
• Subjects: Cellular activation; Cytoskeleton rearrangement; Cytotoxicity, Immunologic; immune synapse; Immunology; NKp46; cellular activation; NKp46; immune synapse; cytotoxicity; cytoskeleton rearrangement

Natural killer (NK) cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell surface expressed inhibitory and activating receptors. NKp46 is a major NK cell-activating receptor that is involved in...