The PRC2 molecule EED is a target of epigenetic therapy for neuroblastoma

• Published in: European journal of cell biology Vol. 101; no. 3; p. 151238
• Main Authors: Shaliman, Dilibaerguli, Takenobu, Hisanori, Sugino, Ryuichi P., Ohira, Miki, Kamijo, Takehiko
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.06.2022; Elsevier
• Subjects: Cell Proliferation - genetics; EED; Epigenesis, Genetic; Histone code; Humans; N-Myc Proto-Oncogene Protein - genetics; N-Myc Proto-Oncogene Protein - metabolism; Neuroblastoma; Neuroblastoma - drug therapy; Neuroblastoma - genetics; Neuroblastoma - metabolism; Polycomb; Polycomb Repressive Complex 2 - genetics; Polycomb Repressive Complex 2 - metabolism; Polycomb; Neuroblastoma; EED; Histone code

Epigenetic modifications by polycomb repressive complex (PRC) molecules appear to play a role in the tumorigenesis and aggressiveness of neuroblastoma (NB). Embryonic ectoderm development (EED) is a member of the PRC2 complex that binds to the H3K27me3 mark deposited by EZH2 via propagation on adjac...