The value of circulating CYFRA21-1 expression in patients with nasopharyngeal carcinoma: a study of 529 subjects

• Published in: International journal of clinical oncology Vol. 21; no. 6; pp. 1038 - 1045
• Main Authors: Song, Xin-mao, Wang, Zhu-jian, Cao, Wen-jun, Ji-Li, Chen, Fu, Wang, Sheng-zi
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.12.2016; Springer Nature B.V
• Subjects: Adult; Antibodies, Viral - blood; Antigens, Neoplasm - blood; Biomarkers; Biomarkers, Tumor - blood; Cancer Research; Carcinoma; Chemoradiotherapy - methods; Female; Herpesvirus 4, Human - immunology; Humans; Keratin-19 - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - blood; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - virology; Neoplasm Staging; Oncology; Original Article; Patient Outcome Assessment; Prognosis; Radiation therapy; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; Statistics as Topic; Surgical Oncology; Throat cancer; Tumors; Nasopharyngeal carcinoma; Tumor biomarker; Epstein–Barr virus antibodies; Cytokeratin 19 fragment 21.1

Background Early diagnosis of nasopharyngeal carcinoma (NPC) needs more reliable biomarkers. The aim of this study was to investigate serum cytokeratin 19 fragment 21.1 (CYFRA21-1) as an NPC biomarker based on data from a large sample. Methods From October 2010 to February 2014, 529 subjects were en...