Chemokines as novel and versatile reagents for flow cytometry and cell sorting

• Published in: The Journal of immunology (1950) Vol. 192; no. 12; pp. 6120 - 6130
• Main Authors: Le Brocq, Michelle L, Fraser, Alasdair R, Cotton, Graham, Woznica, Kerry, McCulloch, Clare V, Hewitt, Kay D, McKimmie, Clive S, Nibbs, Robert J B, Campbell, John D M, Graham, Gerard J
• Format: Journal Article
• Language: English
• Published: United States 15.06.2014
• Subjects: Animals; Chemokine CCL19 - chemistry; Chemokine CCL19 - immunology; Female; Flow Cytometry - methods; Humans; Male; Mice; Receptors, CCR7 - chemistry; Receptors, CCR7 - immunology

Cell therapy regimens are frequently compromised by low-efficiency cell homing to therapeutic niches. Improvements in this regard would enhance effectiveness of clinically applicable cell therapy. The major regulators of tissue-specific cellular migration are chemokines, and therefore selection of t...