Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury

Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO − ) can be a potential indicator to...

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Published inChemical science (Cambridge) Vol. 15; no. 2; pp. 757 - 764
Main Authors Wu, Yueci, Sun, Lu-Lu, Han, Hai-Hao, He, Xiao-Peng, Cao, Weiguo, James, Tony D
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 03.01.2024
The Royal Society of Chemistry
Subjects
Carbon dots
Chemistry
Fluorescent indicators
Injuries
Liver
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Abstract Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO − ) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO − in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD-N-I was developed to detect ONOO − with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide-isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD-N-I we were able to detect exogenous ONOO − in live cells and endogenous ONOO − in APAP-induced liver injury of HepG2 cells. Ratiometric FRET-based probe CD-N-I was developed to detect exogenous ONOO − in live cells and endogenous ONOO − in APAP-induced liver injury of HepG2 cells.
AbstractList Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO-) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO- in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD-N-I was developed to detect ONOO- with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide-isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD-N-I we were able to detect exogenous ONOO- in live cells and endogenous ONOO- in APAP-induced liver injury of HepG2 cells.Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO-) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO- in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD-N-I was developed to detect ONOO- with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide-isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD-N-I we were able to detect exogenous ONOO- in live cells and endogenous ONOO- in APAP-induced liver injury of HepG2 cells.
Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO−) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO− in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD–N-I was developed to detect ONOO− with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide–isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD–N-I we were able to detect exogenous ONOO− in live cells and endogenous ONOO− in APAP-induced liver injury of HepG2 cells.
Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO − ) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO − in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD–N-I was developed to detect ONOO − with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide–isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD–N-I we were able to detect exogenous ONOO − in live cells and endogenous ONOO − in APAP-induced liver injury of HepG2 cells. Ratiometric FRET-based probe CD–N-I was developed to detect exogenous ONOO − in live cells and endogenous ONOO − in APAP-induced liver injury of HepG2 cells.
Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO − ) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO − in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD-N-I was developed to detect ONOO − with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide-isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD-N-I we were able to detect exogenous ONOO − in live cells and endogenous ONOO − in APAP-induced liver injury of HepG2 cells. Ratiometric FRET-based probe CD-N-I was developed to detect exogenous ONOO − in live cells and endogenous ONOO − in APAP-induced liver injury of HepG2 cells.
Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO ) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD-N-I was developed to detect ONOO with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide-isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD-N-I we were able to detect exogenous ONOO in live cells and endogenous ONOO in APAP-induced liver injury of HepG2 cells.
Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be prevented if treatment by the offending drug is discontinued. Recent research indicates that peroxynitrite (ONOO − ) can be a potential indicator to diagnose DILI at an early stage. Therefore, the establishment of an assay to detect and track ONOO − in DILI cases is urgently needed. Here, a FRET-based ratiometric nano fluorescent probe CD–N-I was developed to detect ONOO − with high selectivity and excellent sensitivity. This probe consists of carbon dots and a naphthalimide–isatin peroxynitrite sensing system assembled based on electrostatic interactions. Using CD–N-I we were able to detect exogenous ONOO − in live cells and endogenous ONOO − in APAP-induced liver injury of HepG2 cells.
Author Wu, Yueci
Han, Hai-Hao
James, Tony D
Sun, Lu-Lu
Cao, Weiguo
He, Xiao-Peng
AuthorAffiliation Chinese Academy of Sciences
Shanghai University
Frontiers Center for Materiobiology and Dynamic Chemistry
Henan Normal University
Feringa Nobel Prize Scientist Joint Research Center
The International Cooperation Laboratory on Signal Transduction
University of Bath
East China University of Science and Technology
Shandong Laboratory of Yantai Drug Discovery
Eastern Hepatobiliary Surgery Hospital
Bohai Rim Advanced Research Institute for Drug Discovery
Department of Chemistry
Key Laboratory for Advanced Materials
National Center for Liver Cancer
Shanghai Institute of Materia Medica
School of Chemistry and Molecular Engineering
Molecular Imaging Center
Joint International Research Laboratory of Precision Chemistry and Molecular Engineering
School of Chemistry and Chemical Engineering
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/38179535$$D View this record in MEDLINE/PubMed
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Snippet Drug-induced liver injury (DILI) is the most common cause for acute liver failure in the USA and Europe. However, most of DILI cases can recover or be...
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SubjectTerms Carbon dots
Chemistry
Fluorescent indicators
Injuries
Liver
Title Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury
URI https://www.ncbi.nlm.nih.gov/pubmed/38179535
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