Asymmetric hydrogenation of N-alkyl and N-aryl ketimines using chiral cationic Ru(diamine) complexes as catalysts: the counteranion and solvent effects, and substrate scope

• Published in: Tetrahedron Vol. 68; no. 26; pp. 5248 - 5257
• Main Authors: Chen, Fei, Ding, Ziyuan, He, Yanmei, Qin, Jie, Wang, Tianli, Fan, Qing-Hua
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.07.2012; Elsevier
• Subjects: amines; Anions; Asymmetric catalysis; Bearing; Catalysis; Catalysts; Cationic; Chemistry; Chemistry, Organic; Diamine ligand; enantiomers; Hydrogenation; Imines; Ketimines; methylene chloride; phosphoric acid; Physical Sciences; Ruthenium; Science & Technology; solvents; Diamine ligand; Ruthenium; Ketimines; Asymmetric catalysis; Hydrogenation; ALDOL ADDITIONS; PHOSPHINE-OXAZOLINE LIGANDS; C-SYMMETRIC COPPER(II) COMPLEXES; ACYCLIC IMINES; KETONES; HIGHLY ENANTIOSELECTIVE HYDROGENATION; IRIDIUM COMPLEXES; LEWIS-ACIDS; EFFICIENT; REDUCTIVE AMINATION

Asymmetric hydrogenation of N-alkyl and N-aryl ketimines catalyzed by chiral cationic η6-arene-(N-monosulfonylated diamine) Ru(II) complexes has been investigated. Strong counteranion and solvent effects on the enantioselectivity were observed. The ruthenium catalyst bearing non-coordinating BArF− a...