Case-Control Evaluation of the Effectiveness of the G1P[8] Human Rotavirus Vaccine during an Outbreak of Rotavirus G2P[4] Infection in Central Australia

• Published in: Clinical infectious diseases Vol. 52; no. 2; pp. 191 - 199
• Main Authors: Snelling, T. L., Andrews, R. M., Kirkwood, C. D., Culvenor, S., Carapetis, J. R.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.01.2011
• Subjects: ARTICLES AND COMMENTARIES; Australia - epidemiology; Biological and medical sciences; Case-Control Studies; Children; Clinical medicine; Disease Outbreaks; Dosage; Epidemics; Female; Gastroenteritis; Genotype; Hospitalization; Hospitalization - statistics & numerical data; Humans; Immunization; Infant; Infections; Infectious diseases; Male; Medical sciences; Rotavirus; Rotavirus - classification; Rotavirus - genetics; Rotavirus - isolation & purification; Rotavirus Infections - epidemiology; Rotavirus Infections - prevention & control; Rotavirus vaccines; Rotavirus Vaccines - administration & dosage; Rotavirus Vaccines - immunology; Vaccination; Vaccines; Viral diseases; Viruses; Australia; Oceania; Epidemic; Rotavirus; Human rotavirus; Gastroenteritis; Check; Vaccine; Reoviridae; Infection; Virus; Prevention; Immunoprophylaxis; Viral disease; Digestive diseases; Intestinal disease; Gastric disease

The human rotavirus vaccine was evaluated during an outbreak of rotavirus G2P[4] infection in central Australia. No overall protective effect against hospitalization was demonstrated, raising concerns over the durability of vaccine protection against heterotypic strains. Background. Two and a half y...