Clinical Efficacy and Safety of Naltrexone Combination Therapy in Older Patients with Severe Pruritus

Severe pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral medication because of underlying diseases, possible interaction with concurrent medications, and poor general condition. We evaluated the efficacy and safety of...

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Published inAnnals of dermatology Vol. 28; no. 2; pp. 159 - 163
Main Authors Lee, Jungsoo, Shin, Jung U, Noh, Seongmin, Park, Chang Ook, Lee, Kwang Hoon
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Dermatological Association; The Korean Society for Investigative Dermatology 01.04.2016
대한피부과학회
Subjects
Original
피부과학
Naltrexone
Elderly
Pruritus
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Abstract Severe pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral medication because of underlying diseases, possible interaction with concurrent medications, and poor general condition. We evaluated the efficacy and safety of naltrexone (Revia®), an opioid antagonist, in elderly patients with severe pruritus that was not easily controlled with conventional antipruritics. Eighteen patients were enrolled, with a mean age of 73 years. They additionally received 50 mg of naltrexone per day for an average of 2 months. Using the visual analogue scale, 13 (72.2%) of 18 patients showed a "much improved" condition, reporting more than a 50% decrease in pruritus intensity. Sixteen (88.9%) showed symptomatic improvement, and only 2 (11.1%) had persistent pruritus. Five patients reported side effects including insomnia, fatigue, constipation, and anorexia. However, reactions were either limited to the first 2 weeks or well managed. Naltrexone could be an effective and safe alternative treatment option to control severe pruritus in older patients.
AbstractList BACKGROUNDSevere pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral medication because of underlying diseases, possible interaction with concurrent medications, and poor general condition. OBJECTIVEWe evaluated the efficacy and safety of naltrexone (Revia®), an opioid antagonist, in elderly patients with severe pruritus that was not easily controlled with conventional antipruritics. METHODSEighteen patients were enrolled, with a mean age of 73 years. They additionally received 50 mg of naltrexone per day for an average of 2 months. RESULTSUsing the visual analogue scale, 13 (72.2%) of 18 patients showed a "much improved" condition, reporting more than a 50% decrease in pruritus intensity. Sixteen (88.9%) showed symptomatic improvement, and only 2 (11.1%) had persistent pruritus. Five patients reported side effects including insomnia, fatigue, constipation, and anorexia. However, reactions were either limited to the first 2 weeks or well managed. CONCLUSIONNaltrexone could be an effective and safe alternative treatment option to control severe pruritus in older patients.
Background: Severe pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral medication because of underlying diseases, possible interaction with concurrent medications, and poor general condition. Objective: We evaluated the efficacy and safety of naltrexone (ReviaⓇ), an opioid antagonist, in elderly patients with severe pruritus that was not easily controlled with conventional antipruritics. Methods: Eighteen patients were enrolled, with a mean age of 73 years. They additionally received 50 mg of naltrexone per day for an average of 2 months. Results: Using the visual analogue scale, 13 (72.2%) of 18 patients showed a “much improved” condition, reporting more than a 50% decrease in pruritus intensity. Sixteen (88.9%) showed symptomatic improvement, and only 2 (11.1%) had persistent pruritus. Five patients reported side effects including insomnia, fatigue, constipation, and anorexia. However, reactions were either limited to the first 2 weeks or well managed. Conclusion: Naltrexone could be an effective and safe alternative treatment option to control severe pruritus in older patients. KCI Citation Count: 8
Severe pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral medication because of underlying diseases, possible interaction with concurrent medications, and poor general condition. We evaluated the efficacy and safety of naltrexone (Revia®), an opioid antagonist, in elderly patients with severe pruritus that was not easily controlled with conventional antipruritics. Eighteen patients were enrolled, with a mean age of 73 years. They additionally received 50 mg of naltrexone per day for an average of 2 months. Using the visual analogue scale, 13 (72.2%) of 18 patients showed a "much improved" condition, reporting more than a 50% decrease in pruritus intensity. Sixteen (88.9%) showed symptomatic improvement, and only 2 (11.1%) had persistent pruritus. Five patients reported side effects including insomnia, fatigue, constipation, and anorexia. However, reactions were either limited to the first 2 weeks or well managed. Naltrexone could be an effective and safe alternative treatment option to control severe pruritus in older patients.
Author Lee, Kwang Hoon
Shin, Jung U
Park, Chang Ook
Lee, Jungsoo
Noh, Seongmin
AuthorAffiliation Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea
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Issue 2
Keywords Naltrexone
Elderly
Pruritus
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Snippet Severe pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral medication because...
BACKGROUNDSevere pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral...
Background: Severe pruritus is a challenging condition, and it is more difficult to deal with in older patients due to their limitations in taking oral...
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피부과학
Title Clinical Efficacy and Safety of Naltrexone Combination Therapy in Older Patients with Severe Pruritus
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ispartofPNX Annals of Dermatology, 2016, 28(2), , pp.159-163
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