Influence of Tacrolimus and Ciprofloxacin on Glucose Metabolism
Tacrolimus is an immunosuppressive drug that causes glucose intolerance. On the other hand, ciprofloxacin, which is widely used in the treatment of infectious diseases, is known to cause hypoglycemia as a side effect. We investigated the effects of tacrolimus and ciprofloxacin on serum glucose and i...
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Published in | YAKUGAKU ZASSHI Vol. 127; no. 11; pp. 1883 - 1889 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | Japanese English |
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Japan
The Pharmaceutical Society of Japan
01.11.2007
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Abstract | Tacrolimus is an immunosuppressive drug that causes glucose intolerance. On the other hand, ciprofloxacin, which is widely used in the treatment of infectious diseases, is known to cause hypoglycemia as a side effect. We investigated the effects of tacrolimus and ciprofloxacin on serum glucose and insulin levels in rats, as well as on insulin secretion and the viability of HIT-T15 cells. The rats received intraperitoneal injections of tacrolimus and/or ciprofloxacin for 1 week, and their arterial blood was sampled after the administration of glucose. HIT-T15 cells were cultured in the presence of tacrolimus and/or ciprofloxacin, and the insulin level in the supernatant was measured. Ciprofloxacin did not show a significant effect on serum glucose and insulin levels after multiple administrations in the rats. In contrast, rats in the tacrolimus treatment group showed low serum insulin and high serum glucose levels. Moreover, the coadministration of ciprofloxacin and tacrolimus resulted in higher glucose levels compared with tacrolimus alone 0.5 h after glucose stimulation. In addition, we observed that the rats administered tacrolimus and/or ciprofloxacin had low body weight and food intake. Tacrolimus caused a dose-dependent decrease in the viability of the HIT-T15 cells. Furthermore, both drugs were highly toxic to HIT-T15 cells. In contrast, tacrolimus alone and coadministration of the drugs resulted in no significant difference in insulin secretion. These results suggest that the cytotoxic effects of ciprofloxacin and tacrolimus cause a decrease in insulin secretion, leading to glucose intolerance. |
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AbstractList | Tacrolimus is an immunosuppressive drug that causes glucose intolerance. On the other hand, ciprofloxacin, which is widely used in the treatment of infectious diseases, is known to cause hypoglycemia as a side effect. We investigated the effects of tacrolimus and ciprofloxacin on serum glucose and insulin levels in rats, as well as on insulin secretion and the viability of HIT-T15 cells. The rats received intraperitoneal injections of tacrolimus and/or ciprofloxacin for 1 week, and their arterial blood was sampled after the administration of glucose. HIT-T15 cells were cultured in the presence of tacrolimus and/or ciprofloxacin, and the insulin level in the supernatant was measured. Ciprofloxacin did not show a significant effect on serum glucose and insulin levels after multiple administrations in the rats. In contrast, rats in the tacrolimus treatment group showed low serum insulin and high serum glucose levels. Moreover, the coadministration of ciprofloxacin and tacrolimus resulted in higher glucose levels compared with tacrolimus alone 0.5 h after glucose stimulation. In addition, we observed that the rats administered tacrolimus and/or ciprofloxacin had low body weight and food intake. Tacrolimus caused a dose-dependent decrease in the viability of the HIT-T15 cells. Furthermore, both drugs were highly toxic to HIT-T15 cells. In contrast, tacrolimus alone and coadministration of the drugs resulted in no significant difference in insulin secretion. These results suggest that the cytotoxic effects of ciprofloxacin and tacrolimus cause a decrease in insulin secretion, leading to glucose intolerance. |
Author | ARAI, Shigeaki NAGAFUJI, Takami KIHIRA, Kenji GOUHARA, Takako MORITA, Shushi SATO, Eiji MIYAKE, Katsushi TAYAMA, Yoshitaka KITAURA, Teruaki |
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Snippet | Tacrolimus is an immunosuppressive drug that causes glucose intolerance. On the other hand, ciprofloxacin, which is widely used in the treatment of infectious... |
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SubjectTerms | Animals Anti-Infective Agents - adverse effects Anti-Infective Agents - pharmacology Body Weight - drug effects Cell Survival - drug effects Cells, Cultured ciprofloxacin Ciprofloxacin - adverse effects Ciprofloxacin - pharmacology Cricetinae Dose-Response Relationship, Drug Eating - drug effects Glucose - metabolism Glucose Intolerance - chemically induced glucose tolerance Hypoglycemia - chemically induced Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacology insulin Insulin - metabolism Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Male Rats Rats, Wistar tacrolimus Tacrolimus - adverse effects Tacrolimus - pharmacology |
Title | Influence of Tacrolimus and Ciprofloxacin on Glucose Metabolism |
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