Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats
Sudden exposure of nonacclimatized individuals to high altitude can easily lead to high altitude illnesses. High altitude pulmonary edema (HAPE) is the most lethal form of high altitude illness. The present study was designed to investigate the ability of Rhodiola crenulata extract (RCE), an herbal...
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Published in | Evidence-based complementary and alternative medicine Vol. 2013; no. 2013; pp. 1 - 9 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Cairo, Egypt
Hindawi Puplishing Corporation
01.01.2013
Hindawi Publishing Corporation Hindawi Limited |
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Abstract | Sudden exposure of nonacclimatized individuals to high altitude can easily lead to high altitude illnesses. High altitude pulmonary edema (HAPE) is the most lethal form of high altitude illness. The present study was designed to investigate the ability of Rhodiola crenulata extract (RCE), an herbal medicine traditionally used as an antiacute mountain sickness remedy, to attenuate hypoxia-induced pulmonary injury. Exposure of animals to hypobaric hypoxia led to a significant increase in pathological indicators for pulmonary edema, including the lung water content, disruption of the alveolar-capillary barrier, and protein-rich fluid in the lungs. In addition, hypobaric hypoxia also increased oxidative stress markers, including (ROS) production, (MDA) level, and (MPO) activity. Furthermore, overexpression of plasma (ET-1), (VEGF) in (BALF), and (HIF-1α) in lung tissue was also found. However, pretreatment with RCE relieved the HAPE findings by curtailing all of the hypoxia-induced lung injury parameters. These findings suggest that RCE confers effective protection for maintaining the integrity of the alveolar-capillary barrier by alleviating the elevated ET-1 and VEGF levels; it does so by reducing hypoxia-induced oxidative stress. Our results offer substantial evidence to support arguments in favor of traditional applications of Rhodiola crenulata for antihigh altitude illness. |
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AbstractList | Sudden exposure of nonacclimatized individuals to high altitude can easily lead to high altitude illnesses. High altitude pulmonary edema (HAPE) is the most lethal form of high altitude illness. The present study was designed to investigate the ability of
Rhodiola crenulata
extract (RCE), an herbal medicine traditionally used as an antiacute mountain sickness remedy, to attenuate hypoxia-induced pulmonary injury. Exposure of animals to hypobaric hypoxia led to a significant increase in pathological indicators for pulmonary edema, including the lung water content, disruption of the alveolar-capillary barrier, and protein-rich fluid in the lungs. In addition, hypobaric hypoxia also increased oxidative stress markers, including (ROS) production, (MDA) level, and (MPO) activity. Furthermore, overexpression of plasma (ET-1), (VEGF) in (BALF), and (HIF-1
α
) in lung tissue was also found. However, pretreatment with RCE relieved the HAPE findings by curtailing all of the hypoxia-induced lung injury parameters. These findings suggest that RCE confers effective protection for maintaining the integrity of the alveolar-capillary barrier by alleviating the elevated ET-1 and VEGF levels; it does so by reducing hypoxia-induced oxidative stress. Our results offer substantial evidence to support arguments in favor of traditional applications of
Rhodiola crenulata
for antihigh altitude illness. Sudden exposure of nonacclimatized individuals to high altitude can easily lead to high altitude illnesses. High altitude pulmonary edema (HAPE) is the most lethal form of high altitude illness. The present study was designed to investigate the ability of Rhodiola crenulata extract (RCE), an herbal medicine traditionally used as an antiacute mountain sickness remedy, to attenuate hypoxia-induced pulmonary injury. Exposure of animals to hypobaric hypoxia led to a significant increase in pathological indicators for pulmonary edema, including the lung water content, disruption of the alveolar-capillary barrier, and protein-rich fluid in the lungs. In addition, hypobaric hypoxia also increased oxidative stress markers, including (ROS) production, (MDA) level, and (MPO) activity. Furthermore, overexpression of plasma (ET-1), (VEGF) in (BALF), and (HIF-1α) in lung tissue was also found. However, pretreatment with RCE relieved the HAPE findings by curtailing all of the hypoxia-induced lung injury parameters. These findings suggest that RCE confers effective protection for maintaining the integrity of the alveolar-capillary barrier by alleviating the elevated ET-1 and VEGF levels; it does so by reducing hypoxia-induced oxidative stress. Our results offer substantial evidence to support arguments in favor of traditional applications of Rhodiola crenulata for antihigh altitude illness. Sudden exposure of nonacclimatized individuals to high altitude can easily lead to high altitude illnesses. High altitude pulmonary edema (HAPE) is the most lethal form of high altitude illness. The present study was designed to investigate the ability of Rhodiola crenulata extract (RCE), an herbal medicine traditionally used as an antiacute mountain sickness remedy, to attenuate hypoxia-induced pulmonary injury. Exposure of animals to hypobaric hypoxia led to a significant increase in pathological indicators for pulmonary edema, including the lung water content, disruption of the alveolar-capillary barrier, and protein-rich fluid in the lungs. In addition, hypobaric hypoxia also increased oxidative stress markers, including (ROS) production, (MDA) level, and (MPO) activity. Furthermore, overexpression of plasma (ET-1), (VEGF) in (BALF), and (HIF-1 α ) in lung tissue was also found. However, pretreatment with RCE relieved the HAPE findings by curtailing all of the hypoxia-induced lung injury parameters. These findings suggest that RCE confers effective protection for maintaining the integrity of the alveolar-capillary barrier by alleviating the elevated ET-1 and VEGF levels; it does so by reducing hypoxia-induced oxidative stress. Our results offer substantial evidence to support arguments in favor of traditional applications of Rhodiola crenulata for antihigh altitude illness. |
Author | Chu, Hsin Lee, Shih-Yu Shi, Li-Shian Chang, Tsu-Chung Li, Min-Hui Ho, Cheng-Wen |
AuthorAffiliation | 2 Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 114, Taiwan 3 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan 1 Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan 5 Department of Biochemistry, National Defense Medical Center, P.O. Box 90048-501, Nei-hu, Taipei 114, Taiwan 4 Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan |
AuthorAffiliation_xml | – name: 1 Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan – name: 5 Department of Biochemistry, National Defense Medical Center, P.O. Box 90048-501, Nei-hu, Taipei 114, Taiwan – name: 4 Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan – name: 3 Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan – name: 2 Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 114, Taiwan |
Author_xml | – sequence: 1 fullname: Lee, Shih-Yu – sequence: 2 fullname: Li, Min-Hui – sequence: 3 fullname: Shi, Li-Shian – sequence: 4 fullname: Chu, Hsin – sequence: 5 fullname: Ho, Cheng-Wen – sequence: 6 fullname: Chang, Tsu-Chung |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23710233$$D View this record in MEDLINE/PubMed |
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ContentType | Journal Article |
Contributor | Chu, Hsin Lee, Shih-Yu Shi, Li-Shian Chang, Tsu-Chung Li, Min-Hui Ho, Cheng-Wen |
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Copyright | Copyright © 2013 Shih-Yu Lee et al. Copyright © 2013 Shih-Yu Lee et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2013 Shih-Yu Lee et al. 2013 |
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Snippet | Sudden exposure of nonacclimatized individuals to high altitude can easily lead to high altitude illnesses. High altitude pulmonary edema (HAPE) is the most... |
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SubjectTerms | Alveoli Cardiac arrhythmia Cytokines Edema Exposure Herbal medicine High altitude High-altitude environments Hypoxia Laboratory animals Lungs Medicine Neurosciences Neutrophils Oxidative stress Physiology Proteins Pulmonary hypertension Reactive oxygen species Rhodiola crenulata Rodents Tumor necrosis factor-TNF Vascular endothelial growth factor Water content |
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Title | Rhodiola crenulata Extract Alleviates Hypoxic Pulmonary Edema in Rats |
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