Urinary trans-anti-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene as the most relevant biomarker for assessing carcinogenic polycyclic aromatic hydrocarbons exposure

• Published in: Environment international Vol. 112; no. 1; pp. 147 - 155
• Main Authors: Barbeau, Damien, Lutier, Simon, Choisnard, Luc, Marques, Marie, Persoons, Renaud, Maitre, Anne
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2018; Elsevier
• Subjects: 7,8,9,10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene; absorption; analytical methods; benzo(a)pyrene; Benzopyrenes - analysis; biomarkers; Biomarkers - urine; Biomonitoring; carcinogenicity; Carcinogens - analysis; creatinine; electrodes; Environmental Monitoring; Exposure assessment; half life; Humans; hydrolysis; Life Sciences; Limit of Detection; Linear Models; metabolites; Mixed effects modelling; pollutants; Polycyclic aromatic hydrocarbons; Reproducibility of Results; tobacco; Toxicokinetics; Toxicology; Toxicokinetics; Biomonitoring; 7,8,9,10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene; Polycyclic aromatic hydrocarbons; Exposure assessment; Mixed effects modelling

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous pollutants present as complex mixtures in the environment. Among them, benzo(a)pyrene (BaP) is classified as carcinogenic to humans by the International Agency of Research on Cancer. Taking into account all absorption ways, human biomonitoring al...