Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as novel HIV-1 integrase strand transfer inhibitors

• Published in: RSC advances Vol. 14; no. 13; pp. 92 - 931
• Main Authors: Zhang, Rong-Hong, Chen, Guo-Qi, Wang, Weilin, Wang, Yu-Chan, Zhang, Wen-Li, Chen, Ting, Xiong, Qian-Qian, Zhao, Yong-Long, Liao, Shang-Gao, Li, Yong-Jun, Yan, Guo-Yi, Zhou, Meng
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 14.03.2024; The Royal Society of Chemistry
• Subjects: Benzene; Carboxylic acids; Chemistry; Inhibitors

Integrase plays an important role in the life cycle of HIV-1, and integrase strand transfer inhibitors (INSTIs) can effectively impair the viral replication. However, drug resistance mutations have been confirmed to decrease the efficacy of INSTI during the antiviral therapy. Herein, indole-2-carbox...