The Role of Secreted Frizzled-Related Protein 5 (Sfrp5) in Overweight and Obesity in Childhood and Adolescence

• Published in: Nutrients Vol. 16; no. 18; p. 3133
• Main Authors: Koutaki, Diamanto, Paltoglou, George, Manou, Maria, Vourdoumpa, Aikaterini, Ramouzi, Eleni, Tzounakou, Anastasia-Maria, Michos, Athanasios, Bacopoulou, Flora, Mantzou, Emilia, Zoumakis, Emmanouil, Papadopoulou, Marina, Kassari, Penio, Charmandari, Evangelia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.09.2024; MDPI
• Subjects: Adaptor Proteins, Signal Transducing; Adipocytes; adolescence; Adolescent; Antioxidants - analysis; Antioxidants - metabolism; Biomarkers - blood; Body fat; Body Mass Index; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Child; Child development; childhood; Cytokines - blood; Development and progression; Diabetes; Exercise; Eye Proteins - blood; Female; Glucose; Humans; Inflammation; Insulin resistance; Investigations; Liver diseases; Male; Membrane Proteins - blood; Metabolism; Obesity; Obesity in adolescence; Obesity in children; Overweight; Overweight - blood; Oxidative Stress; Pediatric Obesity - blood; Pediatrics; Proteins; Sfrp5; Sleep; Teenagers; Weight control; Greece; Germany; adolescence; childhood; Sfrp5; overweight; obesity

Secreted frizzled-related protein 5 (Sfrp5) is an anti-inflammatory adipokine that has been implicated in the pathophysiology of obesity and its metabolic complications. Despite the fact that numerous studies have been carried out in adults, limited data on Sfrp5 exist for youth, especially in relat...