Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approach...

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Published inMolecular and cellular endocrinology Vol. 546; p. 111572
Main Authors O'Riordan, Kenneth J., Collins, Michael K., Moloney, Gerard M., Knox, Emily G., Aburto, María R., Fülling, Christine, Morley, Shane J., Clarke, Gerard, Schellekens, Harriët, Cryan, John F.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 15.04.2022
Subjects
acetates
Bacteria
blood-brain barrier
brain
Brain-Gut Axis
butyrates
dietary fiber
digestive system
endocrinology
Fatty Acids, Volatile - metabolism
fermentation
Gastrointestinal Microbiome
intestinal microorganisms
metabolites
Microbiome
Microbiota
Microbiota-gut-brain axis
propionic acid
Short-chain fatty acids
Signal Transduction
therapeutics
Short-chain fatty acids
Microbiota-gut-brain axis
Microbiota
Microbiome
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Abstract The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in this regard have been the short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fibre, which include butyrate, acetate, and propionate. Ongoing research is focused on the entry of SCFAs into systemic circulation from the gut lumen, their migration to cerebral circulation and across the blood brain barrier, and their potential to exert acute and chronic effects on brain structure and function. This review aims to discuss our current mechanistic understanding of the direct and indirect influence that SCFAs have on brain function, behaviour and physiology, which will inform future microbiota-targeted interventions for brain disorders.
AbstractList The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in this regard have been the short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fibre, which include butyrate, acetate, and propionate. Ongoing research is focused on the entry of SCFAs into systemic circulation from the gut lumen, their migration to cerebral circulation and across the blood brain barrier, and their potential to exert acute and chronic effects on brain structure and function. This review aims to discuss our current mechanistic understanding of the direct and indirect influence that SCFAs have on brain function, behaviour and physiology, which will inform future microbiota-targeted interventions for brain disorders.The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in this regard have been the short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fibre, which include butyrate, acetate, and propionate. Ongoing research is focused on the entry of SCFAs into systemic circulation from the gut lumen, their migration to cerebral circulation and across the blood brain barrier, and their potential to exert acute and chronic effects on brain structure and function. This review aims to discuss our current mechanistic understanding of the direct and indirect influence that SCFAs have on brain function, behaviour and physiology, which will inform future microbiota-targeted interventions for brain disorders.
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in this regard have been the short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fibre, which include butyrate, acetate, and propionate. Ongoing research is focused on the entry of SCFAs into systemic circulation from the gut lumen, their migration to cerebral circulation and across the blood brain barrier, and their potential to exert acute and chronic effects on brain structure and function. This review aims to discuss our current mechanistic understanding of the direct and indirect influence that SCFAs have on brain function, behaviour and physiology, which will inform future microbiota-targeted interventions for brain disorders.
ArticleNumber 111572
Author Morley, Shane J.
O'Riordan, Kenneth J.
Fülling, Christine
Knox, Emily G.
Clarke, Gerard
Moloney, Gerard M.
Schellekens, Harriët
Aburto, María R.
Collins, Michael K.
Cryan, John F.
Author_xml – sequence: 1
  givenname: Kenneth J.
  orcidid: 0000-0003-0081-6010
  surname: O'Riordan
  fullname: O'Riordan, Kenneth J.
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 2
  givenname: Michael K.
  orcidid: 0000-0002-9098-5047
  surname: Collins
  fullname: Collins, Michael K.
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 3
  givenname: Gerard M.
  orcidid: 0000-0002-3672-1390
  surname: Moloney
  fullname: Moloney, Gerard M.
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 4
  givenname: Emily G.
  orcidid: 0000-0003-3741-7339
  surname: Knox
  fullname: Knox, Emily G.
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 5
  givenname: María R.
  surname: Aburto
  fullname: Aburto, María R.
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 6
  givenname: Christine
  surname: Fülling
  fullname: Fülling, Christine
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 7
  givenname: Shane J.
  surname: Morley
  fullname: Morley, Shane J.
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 8
  givenname: Gerard
  surname: Clarke
  fullname: Clarke, Gerard
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 9
  givenname: Harriët
  surname: Schellekens
  fullname: Schellekens, Harriët
  organization: APC Microbiome Ireland, University College Cork, Ireland
– sequence: 10
  givenname: John F.
  surname: Cryan
  fullname: Cryan, John F.
  email: J.Cryan@ucc.ie
  organization: APC Microbiome Ireland, University College Cork, Ireland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35066114$$D View this record in MEDLINE/PubMed
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Snippet The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship...
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SubjectTerms acetates
Bacteria
blood-brain barrier
brain
Brain-Gut Axis
butyrates
dietary fiber
digestive system
endocrinology
Fatty Acids, Volatile - metabolism
fermentation
Gastrointestinal Microbiome
intestinal microorganisms
metabolites
Microbiome
Microbiota
Microbiota-gut-brain axis
propionic acid
Short-chain fatty acids
Signal Transduction
therapeutics
Title Short chain fatty acids: Microbial metabolites for gut-brain axis signalling
URI https://dx.doi.org/10.1016/j.mce.2022.111572
https://www.ncbi.nlm.nih.gov/pubmed/35066114
https://www.proquest.com/docview/2622476573
https://www.proquest.com/docview/2636544965
Volume 546
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