Investigation of the Relationship Between Oxidative Stress and Glucose Signaling in Schizosaccharomyces pombe

• Published in: Biochemical genetics Vol. 50; no. 5-6; pp. 336 - 349
• Main Authors: Palabiyik, Bedia, Kig, Cenk, Pekmez, Murat, Dalyan, Levent, Arda, Nazli, Temizkan, Guler
• Format: Journal Article
• Language: English
• Published: Boston Springer-Verlag 01.06.2012; Springer US; Springer Nature B.V
• Subjects: beta -Fructofuranosidase; beta-Fructofuranosidase - genetics; beta-Fructofuranosidase - metabolism; Biochemistry; Biomedical and Life Sciences; Biomedicine; Carbonyl compounds; carbonyls; Catabolite repression; Catalase; Gene expression; Gene regulation; genes; Glucose; Glucose - metabolism; Glutathione peroxidase; Hexokinase; Human Genetics; Intracellular signalling; Medical Microbiology; mutants; oxidation; Oxidative Stress; Pancreatitis-Associated Proteins; Polymerase chain reaction; quantitative polymerase chain reaction; Real-Time Polymerase Chain Reaction; Schizosaccharomyces - genetics; Schizosaccharomyces - metabolism; Schizosaccharomyces pombe; Schizosaccharomyces pombe Proteins - genetics; Schizosaccharomyces pombe Proteins - metabolism; Signal Transduction; stress response; Sucrose; Superoxide dismutase; Superoxide Dismutase - metabolism; Transcription; Transcription factors; Zoology; Glucose repression; Glucose signaling; Fission yeast; Oxidative stress response

The invertase mutant defective in the glucose signaling pathway of Schizosaccharomyces pombe (ird11) is resistant to glucose repression. This mutant is able to consume sucrose alongside glucose and grows in glucose-containing media with a generation time close to that of the wild type. Intracellular...