The Molecular Clock Mediates Leptin-Regulated Bone Formation

• Published in: Cell Vol. 122; no. 5; pp. 803 - 815
• Main Authors: Fu, Loning, Patel, Millan S., Bradley, Allan, Wagner, Erwin F., Karsenty, Gerard
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.09.2005
• Subjects: Animals; Bone Density - drug effects; Bone Density - physiology; Bone Remodeling - drug effects; Bone Remodeling - physiology; Cell Cycle Proteins; Cell Proliferation - drug effects; Circadian Rhythm - genetics; Circadian Rhythm - physiology; Gene Expression Regulation, Developmental - drug effects; Humans; Leptin - metabolism; Leptin - pharmacology; Mice; Mice, Knockout; Nuclear Proteins - deficiency; Nuclear Proteins - genetics; Nuclear Proteins - physiology; Osteoblasts - cytology; Osteoblasts - drug effects; Osteoblasts - physiology; Period Circadian Proteins; Phenotype; Signal Transduction - drug effects; Signal Transduction - physiology; Stromal Cells - drug effects; Stromal Cells - physiology; Sympathetic Nervous System - metabolism; Transcription Factor AP-1 - drug effects; Transcription Factor AP-1 - genetics; Transcription Factor AP-1 - metabolism; Transcription Factors - deficiency; Transcription Factors - genetics; Transcription Factors - physiology; Non-programmatic

The hormone leptin is a regulator of bone remodeling, a homeostatic function maintaining bone mass constant. Mice lacking molecular-clock components ( Per and Cry), or lacking Per genes in osteoblasts, display high bone mass, suggesting that bone remodeling may also be subject to circadian regulatio...