Longevity-associated mitochondrial DNA 5178 A/C polymorphism modulates effects of daily drinking and cigarette consumption on serum triglyceride levels in middle-aged Japanese men

• Published in: Experimental gerontology Vol. 38; no. 10; pp. 1071 - 1076
• Main Authors: Kokaze, Akatsuki, Ishikawa, Mamoru, Matsunaga, Naomi, Yoshida, Masao, Sekine, Yasuko, Sekiguchi, Kanako, Satoh, Masao, Harada, Matsuko, Teruya, Koji, Takeda, Nobuo, Uchida, Yoshiko, Tsunoda, Tooru, Takashima, Yutaka
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.10.2003
• Subjects: Alcohol Drinking - blood; Alcohol Drinking - genetics; Cigarette consumption; DNA, Mitochondrial - genetics; Drinking frequency; Humans; Lipids - blood; Longevity - genetics; Longevity-associated mitochondrial DNA polymorphism; Male; Middle Aged; Polymorphism, Genetic; Regression Analysis; Smoking - blood; Smoking - genetics; Triglyceride; Triglycerides - blood; Drinking frequency; Triglyceride; Longevity-associated mitochondrial DNA polymorphism; Cigarette consumption

Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density...