Leptin signalling in teleost fish with emphasis in food intake regulation

• Published in: Molecular and cellular endocrinology Vol. 526; p. 111209
• Main Authors: Blanco, Ayelén Melisa, Soengas, José Luis
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.04.2021
• Subjects: adipose tissue; amino acid sequences; carbohydrate metabolism; energy expenditure; Fish; Food intake; genes; Leptin; lipids; liver; mammals; mechanism of action; reproduction; Review; sequence analysis; Fish; Review; Food intake; Leptin

Leptin, the product of the obese (ob or Lep) gene, was first cloned in teleost fish in 2005, more than a decade after its identification in mammals. This was because bony fish and mammalian leptins share a very low amino acid sequence identity, which suggests different functionality of the leptin sy...