Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

• Published in: The Journal of immunology (1950) Vol. 195; no. 1; pp. 277 - 288
• Main Authors: Smallie, Tim, Ross, Ewan A, Ammit, Alaina J, Cunliffe, Helen E, Tang, Tina, Rosner, Dalya R, Ridley, Michael L, Buckley, Christopher D, Saklatvala, Jeremy, Dean, Jonathan L, Clark, Andrew R
• Format: Journal Article
• Language: English
• Published: United States AAI 01.07.2015
• Subjects: Animals; Chemokine CXCL1 - genetics; Chemokine CXCL1 - immunology; Chemokine CXCL2 - genetics; Chemokine CXCL2 - immunology; Dual Specificity Phosphatase 1 - genetics; Dual Specificity Phosphatase 1 - immunology; Gene Expression Regulation; Immunity, Innate; Innate Immunity and Inflammation; Interleukin-10 - genetics; Interleukin-10 - immunology; Lipopolysaccharides - pharmacology; Macrophages - drug effects; Macrophages - immunology; Macrophages - pathology; MAP Kinase Kinase 4 - genetics; MAP Kinase Kinase 4 - immunology; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 11 - genetics; Mitogen-Activated Protein Kinase 11 - immunology; Mitogen-Activated Protein Kinase 14 - genetics; Mitogen-Activated Protein Kinase 14 - immunology; Phosphorylation; Primary Cell Culture; RNA Stability; RNA, Messenger - genetics; RNA, Messenger - immunology; Signal Transduction; Tristetraprolin - genetics; Tristetraprolin - immunology; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - immunology

Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs. It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide...