Immunotherapy biomarkers: the long and winding road

A recent meta-analysis examined and validated biomarkers of response to immune-checkpoint inhibitors (ICIs). Herein, we discuss the findings of this analysis, which are consistent with previously identified determinants of ICI efficacy and demonstrate that some genetic variables influence response a...

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Bibliographic Details
Published inNature reviews. Clinical oncology Vol. 18; no. 6; pp. 323 - 324
Main Authors Alban, Tyler J, Chan, Timothy A
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.06.2021
Subjects
Biological markers
Biomarkers
Cancer
Immune checkpoint inhibitors
Immunization
Immunotherapy
Monoclonal antibodies
Oncology, Experimental
Physiological aspects
T cells
United States
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Summary:A recent meta-analysis examined and validated biomarkers of response to immune-checkpoint inhibitors (ICIs). Herein, we discuss the findings of this analysis, which are consistent with previously identified determinants of ICI efficacy and demonstrate that some genetic variables influence response across multiple cancer types.
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ISSN:1759-4774
1759-4782
DOI:10.1038/s41571-021-00498-w