Asymptomatic Cerebrospinal Fluid HIV-1 Viral Blips and Viral Escape During Antiretroviral Therapy: A Longitudinal Study

• Published in: The Journal of infectious diseases Vol. 214; no. 12; pp. 1822 - 1825
• Main Authors: Edén, Arvid, Nilsson, Staffan, Hagberg, Lars, Fuchs, Dietmar, Zetterberg, Henrik, Svennerholm, Bo, Gisslén, Magnus
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 15.12.2016
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Retroviral Agents - therapeutic use; Cerebrospinal Fluid - virology; Female; HIV Infections - drug therapy; HIV Infections - virology; HIV-1 - isolation & purification; HIV/AIDS; Humans; Infectious Medicine; Infektionsmedicin; Longitudinal Studies; Male; Middle Aged; Neurosciences; Neurovetenskaper; Retrospective Studies; RNA, Viral - cerebrospinal fluid; Viral Load; Young Adult; HIV-1; CSF blip; CSF escape; NFL; neurofilament; cerebrospinal fluid; neopterin; viral blip
• ISSN: 0022-1899; 1537-6613; 1537-6613
• DOI: 10.1093/infdis/jiw454

We examined longitudinal cerebrospinal fluid (CSF) samples (median, 5 samples/patients; interquartile range [IQR], 3-8 samples/patient) in 75 neurologically asymptomatic human immunodeficiency virus (HIV)-infected patients receiving antiretroviral therapy. Twenty-seven patients (36%) had ≥1 CSF HIV...