Mitochondrial sirtuins, metabolism, and aging

• Published in: Journal of genetics and genomics Vol. 49; no. 4; pp. 287 - 298
• Main Authors: Ji, Zhejun, Liu, Guang-Hui, Qu, Jing
• Format: Journal Article
• Language: English
• Published: China Elsevier Ltd 01.04.2022
• Subjects: Aging-related diseases; epigenetics; genomics; homeostasis; longevity; metabolism; Metabolism and aging regulation; mitochondria; Mitochondria - genetics; Mitochondria - metabolism; Mitochondrial sirtuins; Phosphatidylinositol 3-Kinases; SIRT3; SIRT4; SIRT5; Sirtuin 3 - genetics; Sirtuin 3 - metabolism; sirtuins; Sirtuins - genetics; Sirtuins - metabolism; SIRT4; SIRT5; Aging-related diseases; Metabolism and aging regulation; Mitochondrial sirtuins; SIRT3

Maintaining metabolic homeostasis is essential for cellular and organismal health throughout life. Multiple signaling pathways that regulate metabolism also play critical roles in aging, such as PI3K/AKT, mTOR, AMPK, and sirtuins (SIRTs). Among them, sirtuins are known as a protein family with versa...