Mitochondria: Roles in pulmonary hypertension

• Published in: The international journal of biochemistry & cell biology Vol. 55; pp. 93 - 97
• Main Authors: Freund-Michel, Véronique, Khoyrattee, Nafiisha, Savineau, Jean-Pierre, Muller, Bernard, Guibert, Christelle
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2014; Elsevier
• Subjects: Alterations; Animals; Arteries; Failure; Glycolysis; Human health and pathology; Humans; Hypertension; Hypertrophy, Right Ventricular - metabolism; Life Sciences; Mitochondria; Mitochondria - metabolism; Mitochondrial dysfunction; Models, Biological; Oxidation-Reduction; Oxidative Phosphorylation; Phosphorylation; Pulmonary arterial remodelling; Pulmonary Artery - metabolism; Pulmonary hypertension; Pulmonology and respiratory tract; Reactive Oxygen Species - metabolism; Right ventricular hypertrophy; Signalling; Right ventricular hypertrophy; Mitochondria; Mitochondrial dysfunction; Pulmonary arterial remodelling; Pulmonary hypertension

Mitochondria are essential cell organelles responsible for ATP production in the presence of oxygen. In the pulmonary vasculature, mitochondria contribute to physiological intracellular signalling pathways through production of reactive oxygen species and play the role of oxygen sensors that coordin...