The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of miR-486-5p and myostatin

• Published in: Archives of biochemistry and biophysics Vol. 692; p. 108511
• Main Authors: Chang, Yun-Ching, Liu, Hung-Wen, Chan, Yin-Ching, Hu, Shu-Hui, Liu, Ming-Yi, Chang, Sue-Joan
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.10.2020
• Subjects: biophysics; catechin; diet; EGCG; epigallocatechin gallate; green tea; inflammation; insulin resistance; lipogenesis; microRNA; miRNA-486-5p; Muscle loss; muscles; Myostatin; oxidative stress; phosphorylation; polyphenols; SAMP8; skeletal muscle; Myostatin; miRNA-486-5p; EGCG; Muscle loss; SAMP8

(−)-Epigallocatechin-3-gallate (EGCG), the most abundant catechin component in green tea, has been reported to attenuate age-associated insulin resistance, lipogenesis and loss of muscle mass through restoring Akt activity in skeletal muscle in our previous and present studies. Accumulated data has...