Investigation on sodium valproate induced germ cell damage, oxidative stress and genotoxicity in male Swiss mice

• Published in: Reproductive toxicology (Elmsford, N.Y.) Vol. 32; no. 4; pp. 385 - 394
• Main Authors: Khan, Sabbir, Ahmad, Tauseef, Parekh, Chintan Vishnubhai, Trivedi, Priyanka Pushkarbhai, Kushwaha, Sapana, Jena, Gopabandhu
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.12.2011; Elsevier
• Subjects: Animals; Anticonvulsants - toxicity; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - analysis; DNA Damage; Embryology: invertebrates and vertebrates. Teratology; Epididymis - pathology; Fundamental and applied biological sciences. Psychology; Genotoxicity; Germ cell; Male; Medical sciences; Mice; Mutagens - toxicity; Neuropharmacology; Organ Size - drug effects; Oxidative Stress; Pharmacology. Drug treatments; Sodium valproate; Sperm Count; Sperm Head - drug effects; Spermatozoa - abnormalities; Spermatozoa - drug effects; Teratology. Teratogens; Testis - chemistry; Testis - metabolism; Testis - pathology; Toxicology; Valproic Acid - toxicity; Germ cell; Oxidative stress; Mice; Sodium valproate; Genotoxicity; 4-Aminobutyrate transaminase; Enzyme; Toxicity; Transferases; Rodentia; Enzyme inhibitor; Male; Anticonvulsant; Valproic acid; Germinal cell; Histone deacetylase inhibitor; Vertebrata; Mammalia; Mouse; Mood stabilizer; Transaminases; Animal; DNA

► Present study reported the role of VPA-induced oxidative stress leading to DNA damage and germ cell toxicity in mice. ► Present results reported at clinical relevant doses, which can aid realistic picture for human risk assessment in clinical setups. ► In present study, we successfully reported th...