Finding and Drugging the Vulnerabilities of RAS-Dependent Cancers
Kinase inhibitors have ushered in the era of targeted therapy, but their utility to date is primarily limited to cancers bearing oncogenic kinase mutations. Two papers in this issue ( Luo et al., 2009; Scholl et al., 2009) could change this landscape by uncovering kinase-specific vulnerabilities in...
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| Published in | Cell Vol. 137; no. 5; pp. 796 - 798 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
29.05.2009
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| Abstract | Kinase inhibitors have ushered in the era of targeted therapy, but their utility to date is primarily limited to cancers bearing oncogenic kinase mutations. Two papers in this issue (
Luo et al., 2009; Scholl et al., 2009) could change this landscape by uncovering kinase-specific vulnerabilities in tumors with RAS mutations. |
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| AbstractList | Kinase inhibitors have ushered in the era of targeted therapy, but their utility to date is primarily limited to cancers bearing oncogenic kinase mutations. Two papers in this issue (Luo et al., 2009; Scholl et al., 2009) could change this landscape by uncovering kinase-specific vulnerabilities in tumors with RAS mutations. Kinase inhibitors have ushered in the era of targeted therapy, but their utility to date is primarily limited to cancers bearing oncogenic kinase mutations. Two papers in this issue ( Luo et al., 2009; Scholl et al., 2009) could change this landscape by uncovering kinase-specific vulnerabilities in tumors with RAS mutations. |
| Author | Sawyers, Charles L. |
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| Cites_doi | 10.1016/j.cub.2006.12.037 10.2174/1568026053507660 10.1126/science.1164382 10.1038/nrc2297 10.1056/NEJMoa0808710 10.1038/nature07385 10.1038/nrc2615 10.1038/nrc1691 |
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| SubjectTerms | Cell Line, Tumor Humans Mutation Neoplasms - drug therapy Protein Kinase Inhibitors - pharmacology ras Proteins - genetics ras Proteins - metabolism |
| Title | Finding and Drugging the Vulnerabilities of RAS-Dependent Cancers |
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