An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs

• Published in: Cell Vol. 135; no. 3; pp. 497 - 509
• Main Authors: Chari, Ashwin, Golas, Monika M., Klingenhäger, Michael, Neuenkirchen, Nils, Sander, Bjoern, Englbrecht, Clemens, Sickmann, Albert, Stark, Holger, Fischer, Utz
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 31.10.2008
• Subjects: HeLa Cells; Humans; Models, Biological; Molecular Chaperones - metabolism; Nerve Tissue Proteins - metabolism; Protein Methyltransferases - chemistry; Protein Methyltransferases - metabolism; Protein-Arginine N-Methyltransferases; Ribonucleoproteins, Small Nuclear - chemistry; Ribonucleoproteins, Small Nuclear - metabolism; RNA; RNA - metabolism; RNA-Binding Proteins - metabolism; Survival of Motor Neuron 1 Protein - metabolism; RNA

Spliceosomal small nuclear ribonucleoproteins (snRNPs) are essential components of the nuclear pre-mRNA processing machinery. A hallmark of these particles is a ring-shaped core domain generated by the binding of Sm proteins onto snRNA. PRMT5 and SMN complexes mediate the formation of the core domai...