Folic acid-capped PEGylated magnetic nanoparticles enter cancer cells mostly via clathrin-dependent endocytosis - Allard-Vannier, Emilie; Hervé-Aubert, Katel; Kaaki, Karine; Blondy, Thibaut; Shebanova, Anastasia; Shaitan, Konstantin V.; Ignatova, Anastasia A.; Saboungi, Marie-Louise; Feofanov, Alexey V.; Chourpa, Igor (Biochimica et biophysica acta. General subjects, 2017)
Keywords: Analytical chemistry; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - metabolism; Antibiotics, Antineoplastic - pharmacology; Bioengineering; Biomaterials; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Cancer; Caveolae - metabolism; Caveolae-dependent endocytosis (CvDE); cell membranes; chemical bonding; chemical elements; Chemical Sciences; Clathrin - metabolism; Clathrin-Coated Vesicles - metabolism; Clathrin-dependent endocytosis (CDE); confocal laser scanning microscopy; Confocal laser-scanning microscopy (CLSM); doxorubicin; Doxorubicin - chemistry; Doxorubicin - metabolism; Doxorubicin - pharmacology; Drug Carriers; Electron energy loss spectroscopy (EELS); Endocytosis; Endosomes - metabolism; Female; fluorescence emission spectroscopy; fluorescent dyes; folic acid; Folic acid (FA); Folic Acid - chemistry; Folic Acid - metabolism; HeLa Cells; High angle annular dark field scanning transmission electron microscopy (HAADF-STEM); Humans; hydrodynamics; Imaging; iron oxides; Life Sciences; lysosomes; Lysosomes - metabolism; Magnetics - methods; Magnetite Nanoparticles - chemistry; MCF-7 Cells; Microscopy, Confocal; Microscopy, Electron, Scanning Transmission; Microscopy, Fluorescence, Multiphoton; Nanomedicine - methods; nanoparticles; neoplasm cells; neoplasms; optical properties; polyethylene glycol; Polyethylene Glycols - chemistry; Spectroscopy, Electron Energy-Loss; Superparamagnetic iron oxide nanoparticles (SPIONs); transmission electron microscopy; Two-photon excited (TPE) fluorescence; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - metabolism; zeta potential; Folic acid (FA); Confocal laser-scanning microscopy (CLSM); High angle annular dark field scanning transmission electron microscopy (HAADF-STEM); Superparamagnetic iron oxide nanoparticles (SPIONs); Clathrin-dependent endocytosis (CDE); Caveolae-dependent endocytosis (CvDE); Two-photon excited (TPE) fluorescence; Electron energy loss spectroscopy (EELS)