Broadband terahertz time-domain spectroscopy of drugs-of-abuse and the use of principal component analysis

Terahertz frequency time-domain spectroscopy has been used to analyse a wide range of samples containing cocaine hydrochloride, heroin and ecstasy--common drugs-of-abuse. We investigated real-world samples seized by law enforcement agencies, together with pure drugs-of-abuse, and pure drugs-of-abuse...

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Published inAnalyst (London) Vol. 134; no. 8; pp. 1658 - 1668
Main Authors BURNETT, Andrew D, WENHUI FAN, UPADHYA, Prashanth C, CUNNINGHAM, John E, HARGREAVES, Michael D, MUNSHI, Tasnim, EDWARDS, Howell G. M, LINFIELD, Edmund H, GILES DAVIES, A
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 01.01.2009
Subjects
Analytical chemistry
Chemistry
Cocaine - analysis
Exact sciences and technology
Heroin - analysis
Principal Component Analysis
Substance Abuse Detection - methods
Terahertz Imaging
Terahertz Spectroscopy - methods
Cocaine
Feasibility
Drug of abuse
Hydrochlorides
Heroin
Principal component analysis
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Summary:Terahertz frequency time-domain spectroscopy has been used to analyse a wide range of samples containing cocaine hydrochloride, heroin and ecstasy--common drugs-of-abuse. We investigated real-world samples seized by law enforcement agencies, together with pure drugs-of-abuse, and pure drugs-of-abuse systematically adulterated in the laboratory to emulate real-world samples. In order to investigate the feasibility of automatic spectral recognition of such illicit materials by terahertz spectroscopy, principal component analysis was employed to cluster spectra of similar compounds.
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ISSN:0003-2654
1364-5528
DOI:10.1039/b817839a