Endoplasmic reticulum stress and autophagy contributed to cadmium nephrotoxicity in HK-2 cells and Sprague-Dawley rats

• Published in: Food and chemical toxicology Vol. 146; p. 111828
• Main Authors: Li, Jian-Ri, Ou, Yen-Chuan, Wu, Chih-Cheng, Wang, Jiaan-Der, Lin, Shih-Yi, Wang, Ya-Yu, Chen, Wen-Ying, Liao, Su-Lan, Chen, Chun-Jung
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2020
• Subjects: apoptosis; Autophagy; Cadmium; cadmium chloride; cell lines; cell viability; cortex; endoplasmic reticulum; endoplasmic reticulum stress; epithelial cells; epithelium; ER stress; genetic markers; histology; humans; kidneys; Nephrotoxicity; toxicology; ER stress; Cadmium; Autophagy; Nephrotoxicity

Excessive accumulation of cadmium is known to cause nephrotoxicity by targeting renal proximal tubular epithelial cells. Studies showed an essential role of autophagy in cadmium-induced nephrotoxicity; however, its underlying mechanisms accompanied by autophagy are incompletely understood. Using an...