Novel Genetically Engineered Probiotics for Targeted Elimination of Pseudomonas aeruginosa in Intestinal Colonization

• Published in: Biomedicines Vol. 11; no. 10; p. 2645
• Main Authors: Kim, Hyun, Jang, Ju Hye, Jung, In Young, Kim, Ha Rang, Cho, Ju Hyun
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 27.09.2023; MDPI
• Subjects: Antibiotics; Antimicrobial agents; antimicrobial peptide; Antimicrobial peptides; antimicrobial resistance; Bacteria; Cloning; Colonization; Diarrhea; Drug resistance; E coli; engineered probiotics; Enzymes; Escherichia coli Nissle 1917; Genes; Genetic engineering; Homoserine lactones; Intestine; Lungs; Microorganisms; Nosocomial infections; Pathogens; Peptides; Plasmids; Probiotics; Production costs; Proteins; Pseudomonas aeruginosa; Sensors; United States > US; South Korea

The intestinal carriage rates of Pseudomonas aeruginosa are notably elevated in immunosuppressed individuals and hospitalized patients, increasing the risk of infection and antibiotic-associated diarrhea. A potential solution to this issue lies in autonomous antibacterial therapy, remaining inactive...