Extensive substrate profiling of cyclopentadecanone monooxygenase as Baeyer–Villiger biocatalyst reveals novel regiodivergent oxidations

• Published in: Journal of molecular catalysis. B, Enzymatic Vol. 73; no. 1; pp. 9 - 16
• Main Authors: Fink, Michael J., Fischer, Thomas C., Rudroff, Florian, Dudek, Hanna, Fraaije, Marco W., Mihovilovic, Marko D.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2011; Elsevier
• Subjects: Baeyer–Villiger monooxygenases; biocatalysts; Bioconversions. Hemisynthesis; Biological and medical sciences; Biooxygenation; Biotechnology; catalytic activity; Fundamental and applied biological sciences. Psychology; Geissman–Waiss lactone; Methods. Procedures. Technologies; Regioselective biotransformation; retronecine; Terpenones; Geissman–Waiss lactone; Terpenones; Baeyer–Villiger monooxygenases; Regioselective biotransformation; Biooxygenation; Baeyer Villiger reaction; Substrate; Regioselectivity; Geissman-Waiss lactone; Biotransformation; Lactone; Oxidation; Baeyer-Villiger monooxygenases; Biocatalyst

[Display omitted] ► Extensive substrate profile of cyclopentadecanone monooxygenase. ► Comparison of enzyme performance to other BVMOs in light of phylogenetic relations. ► Novel features were discovered in context with regiodivergent biooxygenations. ► Performance of CPDMO is highly novel and compl...