Ampelopsis Radix Protects Dopaminergic Neurons against 1-Methyl-4-phenylpyridinium/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Toxicity in Parkinson’s Disease Models In Vitro and In Vivo

Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study was done to explore whether the standardized extract of Ampelopsis Radix (AJW) protects dopaminergic neurons via antioxidant mechanisms in Par...

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Published inEvidence-based complementary and alternative medicine Vol. 2013; no. 2013; pp. 1 - 9
Main Authors Park, Hanbyeol, Shim, Jin Sup, Kim, Hyo Geun, Lee, Hyejung, Oh, Myung Sook
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2013
Hindawi Publishing Corporation
Hindawi Limited
Subjects
8-Hydroxydeoxyguanosine
Alzheimer's disease
Ampelopsis
Animal models
Antioxidants
Brain
Brain research
Colorimetry
Dopamine
Dopamine receptors
Free radicals
Herbal medicine
Hydroxylase
Immunohistochemistry
Metabolism
Metabolites
Movement disorders
MPTP
Neurodegeneration
Neurodegenerative diseases
Neuroprotection
Neurotoxicity
Oxidative stress
Parkinson's disease
Reactive oxygen species
Toxicity
United States > US
South Korea
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Abstract Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study was done to explore whether the standardized extract of Ampelopsis Radix (AJW) protects dopaminergic neurons via antioxidant mechanisms in Parkinson’s disease (PD) models. The effects of AJW on primary mesencephalic cultures stressed with 1-methyl-4-phenylpyridinium were investigated using tyrosine hydroxylase (TH) immunohistochemistry and reactive oxygen species measurement. The eliminative effects of AJW on the 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) radicals were explored using colorimetric methods. The effects of AJW on the mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were determined by pole test as well as TH and 8-hydroxydeoxyguanosine immunohistochemistry. AJW protected dopaminergic neurons by inhibiting reactive oxygen species generation in vitro. Moreover, AJW showed potent radical scavenging activities in vitro. In the mouse PD model, AJW protected the dopaminergic neurons in the brain, leading to motor improvements. AJW inhibited the MPTP-evoked accumulation of 8-hydroxydeoxyguanosine in the brain. These data suggest that AJW has neuroprotective effects with antioxidant mechanisms in PD models.
AbstractList Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study was done to explore whether the standardized extract of Ampelopsis Radix (AJW) protects dopaminergic neurons via antioxidant mechanisms in Parkinson’s disease (PD) models. The effects of AJW on primary mesencephalic cultures stressed with 1-methyl-4-phenylpyridinium were investigated using tyrosine hydroxylase (TH) immunohistochemistry and reactive oxygen species measurement. The eliminative effects of AJW on the 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) radicals were explored using colorimetric methods. The effects of AJW on the mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were determined by pole test as well as TH and 8-hydroxydeoxyguanosine immunohistochemistry. AJW protected dopaminergic neurons by inhibiting reactive oxygen species generation in vitro . Moreover, AJW showed potent radical scavenging activities in vitro . In the mouse PD model, AJW protected the dopaminergic neurons in the brain, leading to motor improvements. AJW inhibited the MPTP-evoked accumulation of 8-hydroxydeoxyguanosine in the brain. These data suggest that AJW has neuroprotective effects with antioxidant mechanisms in PD models.
Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino(Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study wasdone to explore whether the standardized extract of Ampelopsis Radix (AJW) protects dopaminergicneurons via antioxidant mechanisms in Parkinson’s disease (PD) models. The effects of AJWon primary mesencephalic cultures stressed with 1-methyl-4-phenylpyridinium were investigated usingtyrosine hydroxylase (TH) immunohistochemistry and reactive oxygen species measurement. The eliminative effects of AJW on the 2,2-diphenyl-1-picrylhydrazyl and2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) radicals wereexplored using colorimetric methods. The effects of AJW on the mice treated with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were determined by pole test as wellas TH and 8-hydroxydeoxyguanosine immunohistochemistry. AJW protected dopaminergic neuronsby inhibiting reactive oxygen species generation in vitro. Moreover, AJW showedpotent radical scavenging activities in vitro. In the mouse PD model, AJW protected the dopaminergicneurons in the brain, leading to motor improvements. AJW inhibited the MPTP-evoked accumulation of8-hydroxydeoxyguanosine in the brain. These data suggest that AJW has neuroprotective effects with antioxidant mechanisms in PD models.
Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study was done to explore whether the standardized extract of Ampelopsis Radix (AJW) protects dopaminergic neurons via antioxidant mechanisms in Parkinson’s disease (PD) models. The effects of AJW on primary mesencephalic cultures stressed with 1-methyl-4-phenylpyridinium were investigated using tyrosine hydroxylase (TH) immunohistochemistry and reactive oxygen species measurement. The eliminative effects of AJW on the 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) radicals were explored using colorimetric methods. The effects of AJW on the mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were determined by pole test as well as TH and 8-hydroxydeoxyguanosine immunohistochemistry. AJW protected dopaminergic neurons by inhibiting reactive oxygen species generation in vitro. Moreover, AJW showed potent radical scavenging activities in vitro. In the mouse PD model, AJW protected the dopaminergic neurons in the brain, leading to motor improvements. AJW inhibited the MPTP-evoked accumulation of 8-hydroxydeoxyguanosine in the brain. These data suggest that AJW has neuroprotective effects with antioxidant mechanisms in PD models.
Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study was done to explore whether the standardized extract of Ampelopsis Radix (AJW) protects dopaminergic neurons via antioxidant mechanisms in Parkinson's disease (PD) models. The effects of AJW on primary mesencephalic cultures stressed with 1-methyl-4-phenylpyridinium were investigated using tyrosine hydroxylase (TH) immunohistochemistry and reactive oxygen species measurement. The eliminative effects of AJW on the 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) radicals were explored using colorimetric methods. The effects of AJW on the mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were determined by pole test as well as TH and 8-hydroxydeoxyguanosine immunohistochemistry. AJW protected dopaminergic neurons by inhibiting reactive oxygen species generation in vitro . Moreover, AJW showed potent radical scavenging activities in vitro . In the mouse PD model, AJW protected the dopaminergic neurons in the brain, leading to motor improvements. AJW inhibited the MPTP-evoked accumulation of 8-hydroxydeoxyguanosine in the brain. These data suggest that AJW has neuroprotective effects with antioxidant mechanisms in PD models.
Author Shim, Jin Sup
Park, Hanbyeol
Oh, Myung Sook
Kim, Hyo Geun
Lee, Hyejung
AuthorAffiliation 2 Department of Oriental Pharmaceutical Science, College of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, No. 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
3 Studies of Translational Acupuncture Research (STAR), Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, No. 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
1 Department of Life and Nanopharmaceutical Science, Kyung Hee University, No. 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
AuthorAffiliation_xml – name: 1 Department of Life and Nanopharmaceutical Science, Kyung Hee University, No. 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
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– name: 3 Studies of Translational Acupuncture Research (STAR), Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, No. 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24204389$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1186_s12906_015_0751_z
crossref_primary_10_1155_2019_2684108
crossref_primary_10_1089_rej_2015_1779
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Park, Hanbyeol
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Kim, Hyo Geun
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Copyright Copyright © 2013 Hanbyeol Park et al.
Copyright © 2013 Hanbyeol Park et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
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Snippet Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study...
Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study...
Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino(Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study...
Ampelopsis Radix, the root of Ampelopsis japonica (Thunb.) Makino (Vitaceae), is a herbal medicine which has been widely used in East Asia. The present study...
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StartPage 1
SubjectTerms 8-Hydroxydeoxyguanosine
Alzheimer's disease
Ampelopsis
Animal models
Antioxidants
Brain
Brain research
Colorimetry
Dopamine
Dopamine receptors
Free radicals
Herbal medicine
Hydroxylase
Immunohistochemistry
Metabolism
Metabolites
Movement disorders
MPTP
Neurodegeneration
Neurodegenerative diseases
Neuroprotection
Neurotoxicity
Oxidative stress
Parkinson's disease
Reactive oxygen species
Toxicity
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Title Ampelopsis Radix Protects Dopaminergic Neurons against 1-Methyl-4-phenylpyridinium/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Toxicity in Parkinson’s Disease Models In Vitro and In Vivo
URI https://search.emarefa.net/detail/BIM-464563
https://dx.doi.org/10.1155/2013/346438
https://www.ncbi.nlm.nih.gov/pubmed/24204389
https://www.proquest.com/docview/1710735814
https://search.proquest.com/docview/1449764364
https://pubmed.ncbi.nlm.nih.gov/PMC3800597
Volume 2013
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