Fgf receptor signaling plays a role in lens induction

• Published in: Development (Cambridge) Vol. 128; no. 22; pp. 4425 - 4438
• Main Authors: Faber, S C, Dimanlig, P, Makarenkova, H P, Shirke, S, Ko, K, Lang, R A
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 15.11.2001
• Subjects: Animals; Antigens, Differentiation; bmp7 gene; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins - genetics; Bone Morphogenetic Proteins - metabolism; Cell Division; Crosses, Genetic; DNA-Binding Proteins - biosynthesis; Embryonic Induction; Epithelium; Eye Proteins; Forkhead Transcription Factors; Foxe3 gene; Genes, Reporter; HMGB Proteins; Homeodomain Proteins - biosynthesis; Homeodomain Proteins - genetics; Lens, Crystalline - embryology; Mice; Mice, Transgenic; Models, Genetic; Nuclear Proteins - biosynthesis; Paired Box Transcription Factors; Pax6 gene; PAX6 Transcription Factor; Peptide Fragments - genetics; Peptide Fragments - metabolism; Receptors, Fibroblast Growth Factor - antagonists & inhibitors; Receptors, Fibroblast Growth Factor - genetics; Receptors, Fibroblast Growth Factor - metabolism; Repressor Proteins; Signal Transduction; Sox2 gene; SOXB1 Transcription Factors; Tfr7 gene; Transcription Factors - metabolism; Transforming Growth Factor beta

We describe experiments showing that fibroblast growth factor receptor (Fgfr) signaling plays a role in lens induction. Three distinct experimental strategies were used: (1) using small-molecule inhibitors of Fgfr kinase activity, we showed that both the transcription level and protein expression of...