Heparan Sulfate Biosynthesis Regulation and Variability

• Published in: The journal of histochemistry and cytochemistry Vol. 60; no. 12; pp. 898 - 907
• Main Authors: Kreuger, Johan, Kjellén, Lena
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.12.2012
• Subjects: Animals; biosynthesis; enzyme; GAGosome; Glycosaminoglycans - metabolism; Golgi; heparan sulfate; Heparitin Sulfate - biosynthesis; Heparitin Sulfate - chemistry; Heparitin Sulfate - genetics; Humans; Phosphoadenosine Phosphosulfate - metabolism; Proteoglycans - metabolism; Proteoglycans - secretion; regulation; specificity; Transcription, Genetic; Uridine Diphosphate Sugars - metabolism; enzyme; heparan sulfate; regulation; GAGosome; biosynthesis; specificity; Golgi

Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans (HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including numerous growth factors, cytokines, and morphogens, to affect their tissue distribution and signaling. The heparan sulfate (...